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SCREENING FOR ANTIMICROBIAL, PHYTOCHEMICAL AND ANTIOXIDANT PROFILE OF SOME WILD FRUITS AND SEEDS IN CANAANLAND, OTA, NIGERIA

ABAH, K. A. and OWOLABI, Adebayo Oladipo and Oranusi, S. U. (2017) SCREENING FOR ANTIMICROBIAL, PHYTOCHEMICAL AND ANTIOXIDANT PROFILE OF SOME WILD FRUITS AND SEEDS IN CANAANLAND, OTA, NIGERIA. Journal of Industrial Research and Technology, 6 (1). pp. 136-150.

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Abstract

The spread of antimicrobial resistance among pathogenic microorganisms has rendered most conventional drugs redundant. New sources of antimicrobial agents are being harnessed to develop novel drugs. The antibacterial activity of aqueous and ethanolic extracts of twenty fruits and seeds were evaluated against some multi-drug resistant clinical isolates Staphylococcus aureus, Salmonella typhii, Pseudomonas aeruginiosa and Escherichia coli. Standard methods of antimicrobial and phytochemical assays, DPPH and nitric oxide radical scavenging, total antioxidant capacity and reducing power assays were employed. Broad spectrum antibacterial activity was shown by extracts of six out of the twenty plants: Caryota mitis, Cassia javanica, Syzygium samarangense, Veitchia merrilli, Bauhinia tomentosa and Cassia fistula with inhibition zones ranging from 20:t0.8 to 25:t0.1 mm. The minimum inhibitory and bactericidal concentrations of the extracts were between 7.8 to 31.2 mg/ml and 15.6 and 62.5 mg/ml respectively. Phytochemicals present includes saponins, alkaloids, terpenoids, glycosides and high phenol and flavonoid contents in the range of 71.19 - 50.20mg/100g and 47.14 - 34.42mg/100g respectively. The extracts had considerably high antioxidant activity with IC50 values of 41.121-lg/ml in B. tomentosa and 36.57!-lg/ml in C. fistula. C. mitis had a total antioxidant capacity of 34.89 mg/100g. High phenol and flavonoid contents of the extracts significantly correlated with high antioxidant capacity. The presence of antimicrobial and antioxidant properties in these wild fruits and seeds opens up a new perspective in biotherapy as they could be harnessed as alternative drugs for treatment of microbial infections and management of diseases

Item Type: Article
Uncontrolled Keywords: Resistance; Seeds; Fruits; Biot herapy; Antimicrobial; Degenerative diseases
Subjects: Q Science > Q Science (General)
Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Medicine, Health and Life Sciences > School of Biological Sciences
Depositing User: Mrs Hannah Akinwumi
Date Deposited: 16 Jan 2018 09:04
Last Modified: 16 Jan 2018 09:04
URI: http://eprints.covenantuniversity.edu.ng/id/eprint/10013

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