Ajani, Olayinka O. and Iyaye, King T. and Aderohunmu, D. V. and Olanrewaju, I. O. and Germann, Markus W. and Olorunshola, S. J. and Bello, Babatunde L. (2018) Microwave-assisted synthesis and antibacterial propensity of N0-s-benzylidene-2-propylquinoline- 4-carbohydrazide and N0-((s-1H-pyrrol- 2-yl)methylene)-2-propylquinoline- 4-carbohydrazide motifs. Arabian Journal of Chemistry.
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Abstract
Microwave-assisted approach was utilized as green approach to access a series of 2-pro pylquinoline-4-carbohydrazide hydrazone derivatives 10a-j of aromatic and heteroaromatic aldehydes in highly encouraging yields. It involved four steps reaction which was initiated with ring opening reaction of isatin in a basified environment and subsequent cross-coupling with pentan-2-one to produce compound 7. Esterification of 7 in acid medium led to the formation of compound 8 which was reacted with hydrazine hydrate to access 9 which upon microwave-assisted condensed with aromatic and heteroaromatic aldehydes furnished the targeted compounds 10a-j. The structures of 10aj were confirmed by physico-chemical, elemental analyses and spectroscopic characterization which include UV, FT-IR, 1H and 13C NMR as well as DEPT-135. The targeted compounds 10a-j, alongside with gentamicin clinical standard, were investigated for their antibacterial efficacies using agar diffusion method. 2-Propyl-N0-(pyridine-3-ylmethylene) quinoline-4-carbohydrazide 10j emerged as
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Pfitzinger synthesis; Microwave irradiation; Quinoline; Spectral study; Antibacterial |
| Subjects: | Q Science > Q Science (General) Q Science > QD Chemistry |
| Divisions: | Faculty of Engineering, Science and Mathematics > School of Chemistry |
| Depositing User: | Mrs Patricia Nwokealisi |
| Date Deposited: | 13 Mar 2018 09:59 |
| Last Modified: | 13 Mar 2018 09:59 |
| URI: | http://eprints.covenantuniversity.edu.ng/id/eprint/10376 |
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