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FACILE SYNTHESIS AND SPECTROSCOPIC CHARACTERIZATION OF SULFONAMIDE BEARING DIVERSIFIED CARBOXAMIDE AND HYDRAZINE CARBOXAMIDE MOIETIES

Ajani, Olayinka O. and OWOLABI, Fisayo E. and JOLAYEMI, Emmanuel G. and Olanrewaju, I. O. and Aderohunmu, D. V. (2017) FACILE SYNTHESIS AND SPECTROSCOPIC CHARACTERIZATION OF SULFONAMIDE BEARING DIVERSIFIED CARBOXAMIDE AND HYDRAZINE CARBOXAMIDE MOIETIES. Rasayan J. Chem., 10 (4). pp. 1412-1411. ISSN 0974-1496 | e-ISSN: 0976-0083 |

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Abstract

This current research describes the eco-friendly synthesis of N-(s-phenyl)-3-phenyl-2-(phenyl sulfonamido) propanamides which are sulfonamide bearing diversified carboxamide moieties. The incorporation of amido functionality into the sulfonamide moieties was herein achieved in three steps in a cost-effective manner by starting from cheap amino acid, phenyl alanine which was reacted with benzenesulfonyl chloride to produce sulfonamide which upon subsequent esterification followed by amidation furnished carboxamido-incorporated sulfonamide analogs 9a-j in good to excellent yield. The completion of reaction processes was authenticated with Thin Layer Chromatography (TLC) and the chemical structures were validated through the elemental analysis result as well as spectroscopic means which include FT-IR, UV, 1H and 13C NMR. The technique used herein was found to be efficient and cost-effective for the production of the series of carboxamide diversified sulfonamide derivatives

Item Type: Article
Uncontrolled Keywords: sulfonamide, spectroscopy, column chromatography, condensation, esterification
Subjects: UNSPECIFIED
Divisions: Faculty of Engineering, Science and Mathematics > School of Chemistry
Depositing User: Mrs Patricia Nwokealisi
Date Deposited: 13 Mar 2018 10:30
Last Modified: 13 Mar 2018 10:30
URI: http://eprints.covenantuniversity.edu.ng/id/eprint/10377

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