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The burden of disease attributable to ambient PM2.5-bound PAHs exposure in Nagpur, India

Etchie, Tunde Ogbemi and Sivanesan, Saravanadevi and Etchie, Ayotunde Titilayo and Adewuyi, Gregory Olufemi and Kannan, Krishnamurthi and George, K V and Rao, Padma S (2018) The burden of disease attributable to ambient PM2.5-bound PAHs exposure in Nagpur, India. Chemosphere. (Submitted)

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Polycyclic aromatic hydrocarbons (PAHs) bound to PM2.5 are genotoxic carcinogens that can also elicit non-cancer effects. Previous studies report substantial burdens of PAHs-related lung cancer, but no estimate for other cancer types or non-carcinogenic burden. Here, we assessed the burden of disease, in DALYs/person/year, attributable to thirteen priority PAHs in PM2.5 in Nagpur district, for several endpoints linked to benzo[a]pyrene, to inform policy decision-making for mitigation. We conducted detailed assessment of concentrations of PAHs in nine areas, covering urban, peri-urban and rural environments, from February 2013 to June 2014. PAHs concentrations were converted to benzo[a]pyrene equivalent concentration for cancer and non-cancer effects using relative potency factors and relative toxicity factors derived from quantitative structure-activity relationships, respectively. We derived severity for each endpoint using GBD 2016 dataset. The annual average concentration of total PAHs in Nagpur district was 458±246 ng/m3, and results in 0.011 DALYs/person/year (49,000 DALYs/year), much higher than the WHO reference limit of 1×10-6 DALYs/person/year. PAHs-related burden follow this order: developmental (mostly cardiovascular) impairment (55.1%) > cancer (26.5%) or lung cancer (23.1%) > immunological impairment (18.0%) > reproductive abnormally (0.4%). The estimated DALYs/person/year is high. Mitigation intervention should target combustion sources having the highest level of exposure.

Item Type: Article
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Engineering, Science and Mathematics > School of Chemistry
Depositing User: Dr Ayotunde Etchie
Date Deposited: 20 Mar 2018 11:57
Last Modified: 20 Mar 2018 11:57

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