Rotimi, S. O and Bisi-Adeniyi, Tolulope Dorcas and Adelani, Isaacson and Adegbite, Oluwatobi Samuel (2014) Gas chromatography-mass spectrometry identification of anticancer phytochemicals in Aframomum danielli (LB579). The FASEB journal, 28 (1). ISSN 0892-6638 • Online ISSN: 1530-6860
![[img]](http://eprints.covenantuniversity.edu.ng/style/images/fileicons/application_pdf.png) |
PDF
Download (50kB) |
Abstract
Aframomum danielli is one of the African spices used in folklore medicine for the management of several diseases. This study identified the phytochemical components present in the n-hexane seed extract of the A. danielli by gas chromatography-mass spectrometry (GC-MS) analysis and also evaluated the anti-cancer potential of the identified phytochemicals by performing molecular docking against human Vascular Endothelial Growth Factor (VEGF) using Molegro Virtual Docker. The GC-MS analysis identified the presence of phytochemical components caryophyllene (RT: 18.479), humulene (RT: 19.189), 2-butanone (RT: 22.976), benzenesulfonamide (RT: 31.651) and 2-pyridine acetic acid (RT: 32.446). 2-Butanone was the strongest binding ligand (-65.744 kcal/mol) while caryophyllene was the weakest bind lingand (-56.311 kcal/mol). These compounds showed relative strong docking to VEGF with docking energies comparable to an anticancer drug, bevacizumab (-77.883 kcal/mol). This in silico molecular docking study has shown that these phytochemical components could be responsible for anti-cancer properties of A. danielli.
| Item Type: | Article |
|---|---|
| Subjects: | Q Science > Q Science (General) Q Science > QH Natural history > QH301 Biology |
| Divisions: | Faculty of Medicine, Health and Life Sciences > School of Biological Sciences |
| Depositing User: | Mrs Patricia Nwokealisi |
| Date Deposited: | 23 Mar 2018 11:54 |
| Last Modified: | 23 Mar 2018 11:54 |
| URI: | http://eprints.covenantuniversity.edu.ng/id/eprint/10485 |
Actions (login required)
 |
View Item |
