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Assessment of the Hepatoprotective activity of the seeds of Hunteria umbellata (Hallier F.) on Carbon Tetrachloride (CCl4) Induced Liver Damage in Wistar Albino Rats

Ogunlana, Olubanke Olujoke and Ogunlana, Oluseyi Ebenezer and Adelani, Isaacson and Igbinoba, Angie Osarieme and David, Opetoritse Laju and Adeleye, Oluwaseye Joseph and Udeogu, Stephanie Adaora and Adeyemi , A.O. and Akinyele, Julie Oluranti (2018) Assessment of the Hepatoprotective activity of the seeds of Hunteria umbellata (Hallier F.) on Carbon Tetrachloride (CCl4) Induced Liver Damage in Wistar Albino Rats. In: 2nd International Conference on Applied Sciences (ICAS-2), 2018.

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Abstract

This study was designed to evaluate the hepatoprotective activity of the seeds of Hunteria umbellata (HU) on carbon tetrachloride (CCl4) induced rats. Rats of groups 1 (normal control), 3 and 5 were not treated with CCl4 while rats of groups 2 (negative control), 4 and 6 rats were treated with single dose of CCl4 (2 ml/kg) by intraperitoneal administration. Normal control group 1 rats were given distilled water, groups 3 and 4 rats were given 50 mg/kg of silymarin while groups 5 and 6 rats were given 500 mg/kg of HU. Treatment was administered orally for 28 days and sacrificed on the 29th day after an overnight fast. The weights of the rats were taken before and after the treatment. Blood samples were collected in heparinized tubes and biochemical analysis of liver functions and lipid profile tests were carried out on plasma. There was a significant change (p<0.05) in the levels of alanine aminotransferase, alkaline phosphatase, high density lipoprotein and triglycerides of the CCl4 induced group treated with HU compared to the CCl4 untreated group 2 animals. The results obtained showed that the ethanolic extract of HU has hepatoprotective property.

Item Type: Conference or Workshop Item (Paper)
Subjects: H Social Sciences > H Social Sciences (General)
Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Law, Arts and Social Sciences > School of Social Sciences
Faculty of Medicine, Health and Life Sciences > School of Biological Sciences
Depositing User: Mrs Patricia Nwokealisi
Date Deposited: 25 Jun 2018 10:30
Last Modified: 25 Jun 2018 10:30
URI: http://eprints.covenantuniversity.edu.ng/id/eprint/11032

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