Olubanke, O.O. and Ogunlana, Oluseyi Ebenezer and Lawa, A. T. and Olagunju, J. O. and Akindahunsi, A. A. and Tan, Ning-Hua (2013) Antioxidant and DPPH-Scavenging Activities of Compounds and Ethanolic Extract of the Leaf and Twigs of Caesalpinia bonduc L. Roxb. In: 52nd Annual Meeting and ToxExpoTM, March 10–14, 2013, San Antonio, Texas.
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Abstract
Antioxidant effects of ethanolic extract of Caesalpinia bonduc and its isolated bioactive compounds were evaluated in vitro. The compounds included two new cassane diterpenes, 1α,7α-diacetoxy-5α,6β-dihydroxyl-cass-14(15)-epoxy-16,12-olide (1) and 12α-ethoxyl-1α,14β-diacetoxy-2α,5α-dihydroxyl-cass-13(15)-en-16,12-olide (2); and others, bonducellin (3), 7,4’-dihydroxy-3,11-dehydrohomoisoflavanone blocking the expression of SREBP-1c and FAS through LKB1/SIRT1 and AMPK activation in HepG2 cells, suggesting that CDCQ is a novel AMPK activator with a potential role in the prevention obesity.
| Item Type: | Conference or Workshop Item (Paper) |
|---|---|
| Subjects: | Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology |
| Divisions: | Faculty of Medicine, Health and Life Sciences > School of Biological Sciences |
| Depositing User: | Mrs Patricia Nwokealisi |
| Date Deposited: | 26 Jun 2018 09:15 |
| Last Modified: | 26 Jun 2018 09:15 |
| URI: | http://eprints.covenantuniversity.edu.ng/id/eprint/11057 |
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