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Antioxidant and DPPH-Scavenging Activities of Compounds and Ethanolic Extract of the Leaf and Twigs of Caesalpinia bonduc L. Roxb.

Olubanke, O.O. and Ogunlana, Oluseyi Ebenezer and Lawa, A. T. and Olagunju, J. O. and Akindahunsi, A. A. and Tan, Ning-Hua (2013) Antioxidant and DPPH-Scavenging Activities of Compounds and Ethanolic Extract of the Leaf and Twigs of Caesalpinia bonduc L. Roxb. In: 52nd Annual Meeting and ToxExpoTM, March 10–14, 2013, San Antonio, Texas.

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Abstract

Antioxidant effects of ethanolic extract of Caesalpinia bonduc and its isolated bioactive compounds were evaluated in vitro. The compounds included two new cassane diterpenes, 1α,7α-diacetoxy-5α,6β-dihydroxyl-cass-14(15)-epoxy-16,12-olide (1) and 12α-ethoxyl-1α,14β-diacetoxy-2α,5α-dihydroxyl-cass-13(15)-en-16,12-olide (2); and others, bonducellin (3), 7,4’-dihydroxy-3,11-dehydrohomoisoflavanone blocking the expression of SREBP-1c and FAS through LKB1/SIRT1 and AMPK activation in HepG2 cells, suggesting that CDCQ is a novel AMPK activator with a potential role in the prevention obesity.

Item Type: Conference or Workshop Item (Paper)
Subjects: Q Science > QD Chemistry
Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Medicine, Health and Life Sciences > School of Biological Sciences
Depositing User: Mrs Patricia Nwokealisi
Date Deposited: 26 Jun 2018 09:15
Last Modified: 26 Jun 2018 09:15
URI: http://eprints.covenantuniversity.edu.ng/id/eprint/11057

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