Iweala, E. E. J. and Okeke, C. U.
(2005)
Comparative study of the hypoglycemic and biochemical effects of Catharanthus roseus
(Linn) g. apocynaceae (Madagascar periwinkle) and chlorpropamide (diabenese) on
alloxan-induced diabetic rats.
BIOKEMISTRI.
pp. 149-156.
Abstract
The effect of the aqueous extracts of Catharanthus roseus and chlorpropamide (Diabenese) on
the levels of serum cholesterol, total protein, lipid peroxidation, blood glucose and liver enzymes
were compared in alloxan-induced diabetic rats. Four groups namely A, B, C and D comprising
of nine rats each were used. A and B were administered with chlorpropamide and C. roseus
extracts respectively, while C and D served as diabetic and non-diabetic controls respectively.
The results showed comparatively significant reductions (P�0.05) in the levels of glucose,
protein, cholesterol, lipid peroxidation and liver enzymes in the groups administered C. roseus
extracts and chlorpropamide relative to the controls. The reductions were higher in the groups
treated with C. roseus extract than in the groups treated with diabenese.
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