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In vivo Antiplasmodial Activity of Crude Ethanolic and N-hexane Extracts of Moringa oleifera Leaves

Olasehinde, G. I and Ayanda, Opeyemi Isaac and Egwari, L. O. and Ajayi, A. A. and Awofeso, T. (2016) In vivo Antiplasmodial Activity of Crude Ethanolic and N-hexane Extracts of Moringa oleifera Leaves. INTERNATIONAL JOURNAL OF AGRICULTURE & BIOLOGY, 18 (5). 906-910 . ISSN 1814–9596

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This study was carried out to determine the antiplasmodial activity of leaves of Moringa oleifera. Cold extraction method was carried out on grindedleaves to prepare the crude ethanolic and n-hexane extracts. Mice models (Mus musculus) were passaged with chloroquine resistant Plasmodium berghei,which are similar in morphology, physiology and life cycle to P. falciparumthat infect humans. Stock solutions of 5mg/mL5% DMSO were prepared and the extracts wereadministered atdifferent treatment concentrations, 50mg/kg, 100mg/kgand 200mg/kg body weight over 4days. Positive and negative control groups, Chloroquine diphosphate (25mg/kg) and 5% DMSO,respectively were set up. Crude ethanolic and n-hexane extracts of M. oleiferashowed anti-plasmodial activity at the three different concentrations used. Both crude ethanolic and n-hexane extracts of M. oleiferaleaves showed a significant inhibition of parasitaemia (p < 0.05) ranging from 74.7 to 95.6% for ethanolic extract and 59.3 to 87.9% for n-hexane extract. EC50value of crude ethanolic and n-hexane extractswere 32mg/kg and 42mg/kg body weight,respectively. M.oleifera showed potential for possible future use as an alternative to some conventional drugs.© 2016 Friends Science Publishers

Item Type: Article
Uncontrolled Keywords: Antiplasmodial;Parasitaemia;Moringa oleifera;Nhexane;Ethanolic
Subjects: Q Science > QH Natural history > QH301 Biology
Q Science > QL Zoology
Divisions: Faculty of Medicine, Health and Life Sciences > School of Biological Sciences
Depositing User: Dr Isaac Opeyemi Ayanda
Date Deposited: 18 Sep 2018 10:36
Last Modified: 11 Apr 2019 09:08

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