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Synthesis and Antibacterial Activity of N,N-Diethylamide Bearing Benzenesulfonamide Derivatives

Ajani, Olayinka O. and Familoni, Oluwole B and Echeme, Johnbull O and Wu, Feipeng and Sujiang, Zheng (2013) Synthesis and Antibacterial Activity of N,N-Diethylamide Bearing Benzenesulfonamide Derivatives. American Chemical Science Journal, 3 (1). pp. 34-49. ISSN 2249-0205

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Sulfonamides are known to represent a class of medicinally important compounds which are extensively used as antibacterial agents. Hence, a series of new N,N-diethyl amide bearing sulfonamides (2a-k) were synthesized via amidation of easily prepared benzenesulfonamide precursors (1a-k). The chemical structures of all synthesized compounds were substantiated using spectroscopic means such as IR, Mass spectra and 1H-NMR as well as analytical data. The antimicrobial activity of these compounds along with streptomycin, was investigated on Escherichia coli and Staphylococcus aureus. The results showed that this skeletal framework exhibited marked potency as antibacterial agents. The most active antibacterial agent against both targeted organisms was N,Ndiethyl-1-(phenylsulfonyl) piperidine-2-carboxamide (2b).

Item Type: Article
Uncontrolled Keywords: 2-(Phenylsulfonamido) acetic acid; inhibition zone; N,N-diethylamide; antibacterial study; streptomycin.
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Engineering, Science and Mathematics > School of Chemistry
Depositing User: Mr Olayinka O. AJANI
Date Deposited: 12 Feb 2013 18:53
Last Modified: 12 Feb 2013 18:53

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