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Facile Synthesis and Characterization of New 2,3-Disubstituted Benzimidazole Derivatives

Ajani, Olayinka O. and Ezeoke, Emmanuel K and Edobor-Osoh, Abiola and Ajani, Alice O (2013) Facile Synthesis and Characterization of New 2,3-Disubstituted Benzimidazole Derivatives. International Research Journal of Pure and Applied Chemistry, 3 (1). pp. 10-21. ISSN 2231-3443

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Abstract

Benzimidazoles are known to represent a class of medicinally important compounds which are extensively used as antibacterial agents. Hence, a series of five 2-substitutedbenzimidazole precursors (1a-e) were synthesized via [4 + 1] condensation and imino compound (1f) by simple condensation in the presence of Conc. HCl as catalyst. Synthetic modification of N-1 position was achieved in order to obtain new 5-chloro-2,4-dinitrophenyl bearing 1,2-disubstituted benzimidazole 2a-e and 2f, and 3-chlorobenzyl bearing 1,2-disubstituted benzimidazole 3a-e and 3f in good to excellent yields using a facile approach. The chemical structures of all synthesized compounds were confirmed using spectroscopic means such as UV-visible, IR, Mass spectra, 1H and 13C NMR as well as C, H, N elemental analytical data.

Item Type: Article
Uncontrolled Keywords: Heterocycle; benzimidazole; cycloaddition; carboxylic acid; spectroscopy.
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Engineering, Science and Mathematics > School of Chemistry
Depositing User: Mr Olayinka O. AJANI
Date Deposited: 12 Feb 2013 18:53
Last Modified: 12 Feb 2013 18:53
URI: http://eprints.covenantuniversity.edu.ng/id/eprint/1237

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