Iweala, E. E. J. and Rotimi, S. O and Kanu, Faith and Ogo, Chidiebere (2018) Abstract B047: Biochemical parameters of prostate cancer patients in Nigeria. In: AACR Special Conference: Prostate Cancer: Advances in Basic, Translational, and Clinical Research;, December 2-5, 2017, Orlando, Florida.
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Abstract
The screening of biochemical parameters of cancer patients and their development into reliable and specific diagnostic and prognostic biomarkers has been reported in several studies. The biochemical signature of prostate cancer patients in Nigeria may vary from others and can serve as important leads in discovery of new biomarkers for the disease. This will ultimately provide more information on the specific causes and prognosis of the disease as well as improve its diagnosis and management. This study examined some biochemical parameters including alanine transaminase (ALT), alkaline phosphatase (ALP), low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides (TRIG), reduced glutathione (GSH), lipid peroxidation and peroxidase (POD) in the plasma of prostate cancer patients and controls. The data obtained indicate that there were no significant differences in the ALT, LDL, HDL, and POD while ALP and TRIG were significantly increased. Also, there was a significant reduction in GSH. This indicates the possible implication of ALP, TRIG, and GSH in prostate cancer disease in Nigeria and their potential to be further developed into diagnostic and prognostic biomarkers.
| Item Type: | Conference or Workshop Item (Paper) |
|---|---|
| Subjects: | Q Science > QH Natural history R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine, Health and Life Sciences > School of Biological Sciences Faculty of Medicine, Health and Life Sciences > School of Medicine |
| Depositing User: | Mrs Patricia Nwokealisi |
| Date Deposited: | 11 Mar 2020 11:46 |
| Last Modified: | 11 Mar 2020 11:46 |
| URI: | http://eprints.covenantuniversity.edu.ng/id/eprint/13191 |
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