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Chemistry and pharmacological diversity of quinoxaline motifs as anticancer agents

Ajani, Olayinka O. and NLEBEMUO, TOCHUKWU MARTINS and Adekoya, J. A. and Ogunniran, K. O. and Siyanbola, T. O. and Ajanaku, C. O. (2018) Chemistry and pharmacological diversity of quinoxaline motifs as anticancer agents. Acta Pharm, 69. pp. 177-196.

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Surpassing heart diseases, cancer is taking the lead as the deadliest disease because of its fast rate of spreading in all parts of the world. Tireless commitment to searching for novel therapeutic medicines is a worthwhile adventure in synthetic chemistry because of the drug resistance predica�ment and regular outbreak of new diseases due to abnor�mal cell growth anproliferation. Medicinal chemistry researchers and pharmacists have unveiled quinoxaline templates as precursors of importance and valuable inter�mediates in drug discovery because they have been estab�lished to possess diverse pharmacological potentials. Hence, this review highlights the current versatile routes to accessing functionalized quinoxaline motifs and harness�ing their documented therapeutic potentials for anticancer drug development.

Item Type: Article
Uncontrolled Keywords: quinoxaline, anticancer activity, pharmacophore
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Divisions: Faculty of Engineering, Science and Mathematics > School of Chemistry
Depositing User: Mrs Hannah Akinwumi
Date Deposited: 17 Mar 2021 16:40
Last Modified: 17 Mar 2021 16:40

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