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Microwave assisted synthesis and antimicrobial activity of 2-quinoxalinone-3-hydrazone derivatives

Ajani, Olayinka O. and Obafemi, C. A. and Nwinyi, Obinna and Akinpelu, David A. (2010) Microwave assisted synthesis and antimicrobial activity of 2-quinoxalinone-3-hydrazone derivatives. Bioorganic & Medicinal Chemistry, 18. pp. 214-221.

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A simple and efficient method has been developed for the synthesis of various 2-quinoxalinone-3-hydra-zone derivatives using microwave irradiation technique. The series of 2-quinoxalinone-3-hydrazonederivatives synthesized, were structurally confirmed by analytical and spectral data and evaluated fortheir antimicrobial activities. The results showed that this skeletal framework exhibited marked potencyas antimicrobial agents. The most active antibacterial agent was 3-{2-[1-(6-chloro-2-oxo-2H-chromen-3-yl)ethylidene]hydrazinyl}quinoxalin-2(1H)-one,7while 3-[2-(propan-2-ylidene)hydrazinyl]quinoxalin-2(1H)-one,2appeared to be the most active antifungal agent

Item Type: Article
Uncontrolled Keywords: 3-Hydrazinoquinoxalin-2(1H)-oneAntibacterial activityGram positive bacteriaMicrowave irradiation
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Divisions: Faculty of Engineering, Science and Mathematics > School of Chemistry
Depositing User: Mrs Hannah Akinwumi
Date Deposited: 17 Mar 2021 16:52
Last Modified: 17 Mar 2021 16:52

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