University Links: Home Page | Site Map
Covenant University Repository

Effects of vitamin K dietary supplementation in pulmonary dysfunction induced by 7,12-dimethylbenzaanthracene in rat

Dosumu, O.A. and Rotimi, S.O. and Akintunde, J. and Adeleye, O.O. and Sani, L.O. and Omotosho, O.O. and Osinuga, K.T. and Taiwo, O.A. and Ojo, O.A. (2020) Effects of vitamin K dietary supplementation in pulmonary dysfunction induced by 7,12-dimethylbenzaanthracene in rat. Journal of Biochemical and Molecular Toxicology, 34 (12).

[img] Other (vitamin K dietary supplementation in pulmonary dysfunction)
Download (118kB)


One of the well-known toxicants of the mammary tissue is 7,12-dimethylbenzaanthracene (DMBA). This study was carried out to investigate the possible prophylactic's role of increased dietary intake of vitamin K on the induction of toxicity in the lung tissue. Twenty-eight Wistar albino rats (120-150 g) were randomly divided into different groups. Group 1 served as the control and were fed with a normal diet (containing the recommended daily allowance of vitamin K (0.0075%)). Groups 2 and 3 received a single dose of DMBA (80 mg/kg body weight) intragastically. In addition, group 3 rats were maintained on surplus vitamin K diet (0.075% diet) as against the group 2 animals that were on a normal diet. Group 4 rats were on surplus vitamin K diet (0.075% diet) throughout the experimental period of 16 weeks. Our results revealed that supplementation of diet with surplus vitamin K significantly increased the activities of catalase. Superoxide dismutase, glutathione-S-transferase, and glutathione peroxidase were significantly increased in the serum and lungs when compared with the DMBA-treated group, which was maintained on a normal diet. Significant alterations in malondialdehyde, nitric oxide, granulocyte-macrophage colony-stimulating factor, and interleukin 17F were observed in rats challenged with DMBA-fed normal diets but were normalized in rats with surplus vitamin K. These alterations and reversal were confirmed by histopathology studies. This suggests the prophylactic benefit of increased dietary intake of vitamin K without any observed deleterious effect on DMBA-induced pulmonary toxicity. © 2020 Wiley Periodicals LLC

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: 7,12 dimethylbenzaanthracene; ascorbic acid; biological marker; catalase; eosin; glutathione peroxidase; glutathione transferase; granulocyte macrophage colony stimulating factor; hematoxylin; interleukin 17F; malonaldehyde; nitric oxide; superoxide dismutase; vitamin K group, animal experiment; animal model; animal tissue; antioxidant activity; Article; blood biochemistry; body weight gain; controlled study; data analysis software; diet supplementation; dietary intake; enzyme activity; growth retardation; histopathology; lipid peroxidation; lung alveolus cell; lung alveolus wall; lung homogenate; lung parenchyma; lung toxicity; nonhuman; prophylaxis; rat
Subjects: R Medicine > RS Pharmacy and materia medica
Depositing User: Solomon Rotimi
Date Deposited: 18 Jun 2021 16:00
Last Modified: 18 Jun 2021 16:00

Actions (login required)

View Item View Item