Cytotoxic assessment of xylopia aethiopica dun. a. on human prostate and breast cancer cell lines

Iweala, E.E.J. and Bankole, E.O. and Iheagwam, F.N. and Dania, O.E. and Ntite, U.F. (2020) Cytotoxic assessment of xylopia aethiopica dun. a. on human prostate and breast cancer cell lines. Tropical Journal of Natural Product Research, 4 (12). pp. 1143-1146.

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Abstract

Cancer is associated with the unregulated multiplication of cells in specific parts of the body. Plant-derived products are employed in the treatment and management of such malignant tumours. Prostate and breast cancers are the most common forms affecting Nigerians. Our aim is to investigate the cytotoxic effect of Xylopia aethiopica, a commonly consumed spice in Nigeria, on selected cancer cell lines. The antiproliferative activity of X. aethiopica ethanol extract of varying concentrations was assessed on MDA-MB-231, MCF-7, and LNCaP using MTT assay. A dose-dependent antiproliferative activity was observed. The IC50 for X. aethiopica on the cell lines were � 4.506 ± 0.07 µg/mL except for MCF-7 at 72 hours, where 18.86 ± 0.20 µg/mL was recorded. The findings from this study indicate the potential antiproliferative and cytotoxic property of X. aethiopica on human prostate and breast cancer cell lines. © 2020 Iweala et al.

Item Type:	Article
Additional Information:	cited By 0
Uncontrolled Keywords:	alkaloid; antineoplastic agent; flavonoid; plant extract; saponin; unclassified drug; Xylopia aethiopica extract, antineoplastic activity; antioxidant activity; antiproliferative activity; Article; breast cancer; cell cycle assay; cell proliferation; cell viability; cell viability assay; controlled study; cytotoxicity; human; human cell; IC50; MCF-7 cell line; MDA-MB-231 cell line; medicinal plant; MTT assay; phytochemistry; prostate cancer; Xylopia; Xylopia aethiopica
Subjects:	Q Science > Q Science (General)
Divisions:	UNSPECIFIED
Depositing User:	Franklyn N IHEAGWAM
Date Deposited:	21 Jun 2021 16:00
Last Modified:	21 Jun 2021 16:00
URI:	http://eprints.covenantuniversity.edu.ng/id/eprint/14783

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