Yakubu, Omolara Faith and Metbemu, Damilola S and Adesina, Gbolahan (2020) Protective Roles of Annona senegalensis Pers. Extract in N-Diethylnitrosamine-Induced Hepatocellular Carcinoma in Male Wistar Rats. Tropical Journal of Natural Product Research, 4 (1). pp. 981-984.
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Abstract
Hepatic cancer is a common and leading cancer around the world. Preventive measures have been emphasized in view of its prognosis and limited treatment. This study evaluates the protective roles of Annona senegalensis in N-diethylnitrosamine (DEN) – a model of hepatocarcinoma in male Wistar rats. Rats were intra-peritoneally induced weekly with 100 mg/kg of DEN for 3 weeks and treated with Annona senegalensis extract using a cannula for 21 days. Biochemical assays; aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lipid peroxidation were carried out. Reverse transcription-polymerase chain reactions for the expression of pro-inflammatory RNA, interleukin 6 (IL-6), were equally determined. Annona senegalensis extract (100 mg/kg and 200 mg/kg body weight) significantly (p < 0.05) reduced the activities of ALT and AST in DEN-induced hepatocarcinoma. Lipid peroxidation associated with the DEN model of the hepatocarcinoma was reversed, and the expression of the pro-inflammatory, IL-6 mRNA was also down-regulated with Annona senegalensis extract. Histopathological analysis revealed that the treatment (Annona senegalensis extract) restored the liver architecture in DEN model of hepatocarcinoma. Restoration of the liver enzymes, downregulation of the pro-inflammatory, IL-6 mRNA, and restoration of the liver architecture in the DEN model of hepatocarcinoma corroborated the protective potentials of Annona senegalensis extract against hepatocarcinoma
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | N-diethylnitrosamine, Annona senegalensis, Hepatocellular carcinoma, Gene expression. |
| Subjects: | Q Science > Q Science (General) Q Science > QH Natural history > QH301 Biology |
| Divisions: | Faculty of Medicine, Health and Life Sciences > School of Biological Sciences |
| Depositing User: | Mrs Hannah Akinwumi |
| Date Deposited: | 22 Jun 2021 09:53 |
| Last Modified: | 22 Jun 2021 09:53 |
| URI: | http://eprints.covenantuniversity.edu.ng/id/eprint/14823 |
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