AGBOOLA, OMOWUMI DARLINGTON and Covenant University, Theses (2021) ADSORPTION-DESORPTION BEHAVIOUR AND MECHANISMS OF PYRIMETHAMINE AND METRONIDAZOLE BENZOATE ON POLYSTYRENE, POLYETHYLENE AND POLYETHYLENE TEREPHTHALATE MICROPLASTICSADSORPTION-DESORPTION BEHAVIOUR AND MECHANISMS OF PYRIMETHAMINE AND METRONIDAZOLE BENZOATE ON POLYSTYRENE, POLYETHYLENE AND POLYETHYLENE TEREPHTHALATE MICROPLASTICSADSORPTION-DESORPTION BEHAVIOUR AND MECHANISMS OF PYRIMETHAMINE AND METRONIDAZOLE BENZOATE ON POLYSTYRENE, POLYETHYLENE AND POLYETHYLENE TEREPHTHALATE MICROPLASTICSADSORPTION-DESORPTION BEHAVIOUR AND MECHANISMS OF PYRIMETHAMINE AND METRONIDAZOLE BENZOATE ON POLYSTYRENE, POLYETHYLENE AND POLYETHYLENE TEREPHTHALATE MICROPLASTICSADSORPTION-DESORPTION BEHAVIOUR AND MECHANISMS OF PYRIMETHAMINE AND METRONIDAZOLE BENZOATE ON POLYSTYRENE, POLYETHYLENE AND POLYETHYLENE TEREPHTHALATE MICROPLASTICSADSORPTION-DESORPTION BEHAVIOUR AND MECHANISMS OF PYRIMETHAMINE AND METRONIDAZOLE BENZOATE ON POLYSTYRENE, POLYETHYLENE AND POLYETHYLENE TEREPHTHALATE MICROPLASTICSADSORPTION-DESORPTION BEHAVIOUR AND MECHANISMS OF PYRIMETHAMINE AND METRONIDAZOLE BENZOATE ON POLYSTYRENE, POLYETHYLENE AND POLYETHYLENE TEREPHTHALATE MICROPLASTICSADSORPTION-DESORPTION BEHAVIOUR AND MECHANISMS OF PYRIMETHAMINE AND METRONIDAZOLE BENZOATE ON POLYSTYRENE, POLYETHYLENE AND POLYETHYLENE TEREPHTHALATE MICROPLASTICS. Masters thesis, Covenant University.
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Abstract
Research studies over the years have shown the presence of contaminated plastic debris in the organs of marine organisms. In addition to the problems presented by improper disposal of plastics giving rise to presence of microplastics in the environment, is the sorption of pharmaceuticals on plastic polymers and their persistence which contributes to their long-range transport into the marine environment. Numerous studies have been done to investigate adsorption of different types of antibiotics. However, very little has been done on antimalarial drugs commonly used to treat prevalent malarial disease in Nigeria. This research work aims to investigate the adsorption behaviour of pyrimethamine and metronidazole benzoate on 3 types of plastic polymers which include polystyrene, polyethylene, and polyethylene terephthalate through batch adsorption experiment. Contributing factors like pH, concentration of drug standards, and contact time, were varied to study points of optimal sorption. The pH of aquatic media was varied between 4 and 8 using NaOH and HCl, initial concentration was varied between 20 mg/L and 100 mg/L, while contact time was varied between 0hour and 48hours. The identity of the plastic polymers was confirmed using an FTIR, while HPLC was used to confirm the concentration of the analytes before and after adsorption. Results showed that adsorption increased from 20% to 69% with increase in initial concentration between 20 mg/L and 100 mg/L, adsorption isotherm showed that adsorption best fit into the Langmuir adsorption with a correlation coefficient (R2) of 0.9938, pyrimethamine drug standards led to a slight increase in pH of aquatic media, however, metronidazole benzoate slightly increased pH between 4.0 to 6.0, but led to a reduction in pH of 7.0 down to 6.5 and pH of 8.0 to 7.5 was observed for metronidazole benzoate owing to the pH of MNZ being 4.3. The observed change in pH introduced by pyrimethamine and metronidazole benzoate shows that aquatic life can be influenced adversely on exposure to these drugs.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Adsorption, microplastics, pharmaceuticals, environment. |
| Subjects: | Q Science > Q Science (General) Q Science > QD Chemistry |
| Divisions: | Faculty of Engineering, Science and Mathematics > School of Chemistry |
| Depositing User: | Mrs Hannah Akinwumi |
| Date Deposited: | 08 Nov 2021 12:52 |
| Last Modified: | 08 Nov 2021 12:52 |
| URI: | http://eprints.covenantuniversity.edu.ng/id/eprint/15451 |
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