ELUDIRE, ABIDEMI TEWOGBOLA and Covenant University, Theses (2021) THERAPEUTIC EFFECTS OF CALCIUM AND CALCIUM-D-GLUCARATE IN PROLONGED HIGH MONOSODIUM GLUTAMATE INDUCED ORGANS DAMAGE IN FEMALE RAT. Masters thesis, COVENANT UNIVERSITY.
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Abstract
Monosodium glutamate is a flavour enhancing agent in food processing with threats to public health at a high level. This study is aimed at evaluating the therapeutic effects of calcium, and calcium d glucarate (CDG) on excess monosodium glutamate (MSG) fed female rats. Ninety-six female rats, divided into 10 study groups consisting of the pre-treated and post-treated groups with 9 rats each, and additional 6 rats for baseline were used for this study. Animals in the group 1 and 2 of both pre and post-treatment group served as normal control, and those administered with 750 mg/kg bwt. of MSG intraperitoneally for 70 days respectively. Calcium (440mg/L), CDG (35 mg/kg), and the combined calcium and CDG based diets were respectively administered to groups 3, 4, and 5 of the two pre-treated and post-treated with MSG (750mg/kgbwt). Treatments administered for 14, 28, and 42 days were assessed for their effects on lactate dehydrogenase (LDH), β-glucuronidase, estradiol, and total protein in the serum using appropriate kits. The total protein levels, and the activities of alanine transaminase, aspartate transaminase, in addition to histological examination, were also assessed in the liver, kidney, small intestine, and uterus. The 28 days pre-administration of calcium-d-glucarate as a lone diet increased significantly (p < 0.05) the estrogen level in the rats. The 14 days post-administration of diets composed with calcium, and the calcium-d-glucarate significantly increased (p < 0.05) estrogen level, these two diets significantly reduced (p < 0.05) estrogen level for the remaining period of experimentation, while the combined diets significantly reduced (p < 0.05) the estrogen level throughout the experiment. Both the pre-treated and post-administered calcium-d-glucarate diets significantly reduced (p<0.05) the activity of β-glucuronidase. Also, the 14 days pre-administered calcium diet significantly reduced (p<0.05) the activity of serum alanine transferase. Both the pre-administered calcium and the combined diets significantly reduced (p < 0.05) the LDH activities in the first 28 days of feeding, while the post-administered calcium and calcium-d-glucarate significantly increased (p<0.05) the activities of LDH during the first 28 days feeding. Histology results showed calcium and calcium-d-glucarate were able to extensively reduce the damage in organs. Therefore, foods fortification with both calcium and calcium-d-glucarate are recommended strategies for managing health hazards due to excessive consumption of monosodium glutamate.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Calcium d-glucarate, Monosodium glutamate, Calcium. |
| Subjects: | Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology |
| Divisions: | Faculty of Medicine, Health and Life Sciences > School of Biological Sciences |
| Depositing User: | Mrs Hannah Akinwumi |
| Date Deposited: | 05 Feb 2022 14:39 |
| Last Modified: | 05 Feb 2022 14:39 |
| URI: | http://eprints.covenantuniversity.edu.ng/id/eprint/15604 |
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