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KAYODE-AFOLAYAN, OLUSHOLA DAMILOLA and Covenant University, Theses (2020) PHARMACEUTICAL EFFLUENT TREATMENT USING MICROALGAE Scenedesmus obliquus and Chlorella vulgaris. Masters thesis, COVENANT UNIVERSITY.

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Ineffective effluent treatment contributes to the recalcitrance and bioaccumulation of some active pharmaceutical by-products in the environment. In this study, physicochemical analyses were conducted on effluent sampled from a pharmaceutical company in Ota using spectrophotometric methods. These include inductively coupled plasma-coupled emission spectrometry (ICP-OES), and High-performance liquid chromatography (HPLC). The water quality index (WQI) was deduced from the assessed parameters which included conductivity, total suspended solids (TSS), total dissolved solids (TDS), biochemical oxygen demand (BOD), chemical oxygen demand (COD), biogenic/organic constituents, (phosphates, nitrates, and sulphates), and heavy metals. The microalgae utilized for the treatment of the effluents, were sampled from the environment, and grown for seven days in a BG-11 medium. Following the isolation and characterization of the microalgae using microscopic examinations and molecular characterization, two selected microalgae named Scenedesmus obliquus (MW824580) and Chlorella vulgaris (MW824551) were used in the treatment assay of the pharmaceutical effluents and monitored for 28-days period. The results obtained ranged from BOD (39.10 ± 0.35- 3.03 ± 0.42), COD (360.70± 1.45 - 19.67± 2.60), nitrates (13.26± 0.69 - 1.27± 0.04), sulphates (4.57± 0.14 - 0.34± 0.03), phosphates (4.50± 0.06 - 0.02± 0.02) in mg/L. The pharmaceutical residues assay ranged between (567± 14.0 - 49.50± 2.50) Loratadine, Fluconazole, (2554± 14.50 - 141.50± 7.50) Ciprofloxacin, (510± 5.0 - 64.50±5.50), Diphenhydramine Hcl, (499±4.0 - 37.0± 1.5), and Clotrimazole, (1290± 15.50 - 95.0± 12.50) in ng/L. The WQI for the pharmaceutical effluent is 32.53. After treatment during the 28-day period it was estimated to be 14.14 with a water quality status of ‘Excellent’. From the treatment assay it was evident that Scenedesmus obliquus reduced the TSS, TDS, BOD, COD effluents better than Chlorella vulgaris, however Chlorella vulgaris exhibited more competence with the reduction of active pharmaceutical ingredients. In conclusion, it is evident that microalgae-based technologies could be used effectively in the treatment of pharmaceutical effluents before reuse or eventual discharge into receiving waterbodies to prevent environmental pollution and adverse health effects on the fauna and humans.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Pharmaceutical Effluent, Bioremediation, Microalgae, Heavy Metals, Active Pharmaceutical Ingredients
Subjects: Q Science > Q Science (General)
Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Medicine, Health and Life Sciences > School of Biological Sciences
Depositing User: AKINWUMI
Date Deposited: 02 Aug 2022 14:20
Last Modified: 02 Aug 2022 14:20

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