Mamman, Deborah Caleb and Covenant University, Theses (2022) AFLATOXIN B1 EXPOSURE AND LIPID LEVELS OF PREGNANT WOMEN IN ABEOKUTA, NIGERIA: A Cross-Sectional Study. Masters thesis, Covenant University Ota.
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Abstract
Aflatoxins are mycotoxins produced naturally by the Aspergillus fungi and are commonly found in poorly stored crops. The most toxic of these compounds, aflatoxin B1 (AFB1), has been well studied in pregnant women and has been linked to pre-term delivery, low birth weight, etc. and also causes other adverse health effects on the child due to its ability to cross the placental barrier. Some animal studies indicated that AFB1 increased lipid levels over the normal range. However, there has been few data concerning an association between AFB1 and lipid levels in humans. This study investigated the association between AFB1-albumin adducts and cholesterol, triglyceride and HDL in pregnant women in their first and third trimesters. Cholesterol and triglycerides were analyzed using commercially available kits (Randox), while AFB1-albumin levels were assayed using ELISA kit. All statistical analysis were carried out using stata software package. The mean ± standard deviation values of total cholesterol and total triglycerides showed a significant increase (p < 0.05) from 75.378 ± 29.154 mg/dl and 73.769 ± 23.703 mg/dl in the first trimester to 98.906 ± 26.868 mg/dl and 126.241 ± 29.281 mg/dl in the third trimester, respectively. HDL1 cholesterol levels decreased from 55.734 ± 18.317 mg/dl in the first trimester to 52.79 ± 16.12 mg/dl in the third trimester while HDL2 cholesterol levels increased from 48.127 ± 18.521 mg/dl in the first trimester to 51.243 ± 14.99 mg/dl in the third trimester. HDL1 and HDL2 triglyceride both increased from 40.396 ± 15.935 mg/dl and 28.994 ± 7.678 mg/dl in the first trimester to 47.077 ± 20.968 mg/dl and 30.91 ± 10.161 mg/dl in the third trimester, respectively. AFB1-albumin adducts significantly (p < 0.05) decreased from 8.467 ± 4.812 ng/ml in the first trimester to 6.454 ± 2.725ng/ml in the third trimester. The association between AFB1 albumin adducts and total cholesterol was negatively weak (p = 0.096) in the first trimester and positively weak (p = 0.463) in the third trimester. Likewise that of AFB1-albumin adducts and total triglyceride was negatively weak (p = 0.438) in the first trimester and positively weak in the third (p = 0.051). The results presented in this study showed weak associations between AFB1-albumin adducts and total cholesterol, and AFB1-albumin adduct and total triglyceride in the first trimesters of pregnant women, further studies can be carried out to investigate more on this association.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Aflatoxin B1, lipid levels, pregnant women |
| Subjects: | Q Science > QH Natural history |
| Divisions: | Faculty of Medicine, Health and Life Sciences > School of Biological Sciences |
| Depositing User: | nwokealisi |
| Date Deposited: | 06 Oct 2022 15:02 |
| Last Modified: | 06 Oct 2022 15:02 |
| URI: | http://eprints.covenantuniversity.edu.ng/id/eprint/16283 |
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