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Phytochemical and toxicological evaluations of Prosopis africana (GUILL. and PERR.) extract on albino wistar rats

OBODE, OKUKWE CHRISTA and Adebayo, H. A. and Li, Chunyang (2021) Phytochemical and toxicological evaluations of Prosopis africana (GUILL. and PERR.) extract on albino wistar rats. Toxicol Res, 37. pp. 183-195.

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In this study, we investigated the phytochemical and toxicological impacts of the ethanol leaf extract of Prosopis africana in albino rats. Preliminary phytochemical analysis was done using established methods. Acute and 28-day sub-chronic toxicity evaluations of the extract were carried out in wistar rats. Five groups made up of 8 rats per group were used and treated with 500, 1000, 1500 and 2000 mg/kg b.wt. respectively; while the control group received 1 ml of 10% Tween-20 solution. Phytochemicals detected include tannins, saponins, favonoids, alkaloids, anthocyanin, quinones, terpenoids and steroids. There were no signs of toxicity in the acute toxicity study neither was any death recorded. Weight loss and death were recorded after 18 days of treatment in groups treated with 1500 and 2000 mg/kg b.wt. No signifcant alteration of haematological parameters was observed, however increased WBC count was recorded. Liver and kidney function parameters were signifcantly (p<0.05) reduced, while signifcant (p<0.05) increase in triglycerides with lowered cholesterol was seen when compared with the control group. Histological evaluations of the liver, kidney, heart and testicular tissues revealed normal sections in majority of the animals; however, mild vascular congestions were observed at random doses (liver and heart at 1500 mg/kg b.wt.; kidney at 500 mg/kg b.wt.). Our study shows that ethanol leaf extract of P. africana would probably not cause signifcant toxic efects as indicated by haematological and biochemical parameters. However, there may be need to apply caution in its use at high doses given that death occurred at 1500 mg/kg b.wt. during the repeat-dose toxicity study.

Item Type: Article
Uncontrolled Keywords: Medicinal plants · Prosopis africana · Toxicity Phytochemicals · Wistar rats
Subjects: Q Science > Q Science (General)
Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Medicine, Health and Life Sciences > School of Biological Sciences
Depositing User: AKINWUMI
Date Deposited: 25 Apr 2023 22:25
Last Modified: 25 Apr 2023 22:25

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