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Antibiotic Resistance Status of Pseudomonas aeruginosa in Clinical Isolates in Ogun State

Ohore, Hannah U. and Akinduti, P. A. and Ahuekwe, Eze Frank and Salami, A. O. and Olasehinde, G. I (2022) Antibiotic Resistance Status of Pseudomonas aeruginosa in Clinical Isolates in Ogun State. In: Bioenergy and Biochemical Processing Technologies. SpringerLink, pp. 269-276.

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Pathogenic Gram-negative bacteria mostly produce extended-spectrum beta-lactamases (ESBLs), a feature that confers resistance to some newer generations of antibiotics. The study was aimed at evaluating the antibiotic resistance status of Pseudomonas aeruginosa isolates collected from September to November 2020 from tertiary care hospitals in Ogun State, Nigeria. One hundred fifty isolates from clinical samples (high vaginal swab, wound, urine, ear, blood) were obtained, and their susceptibility pattern was determined against eight antibiotics. Out of the 150 samples, 27 P. aeruginosa were identified. Anti-microbial susceptibility testing was carried out on the isolates using the modified Kirby-Bauer disc diffusion method, and ESBL production was detected phenotypically. The mean age group of the patients was 29.56 years. Gentamicin from the aminoglycoside class showed best activity (74.1%), and ampicillin and penicillin showed little to no activity (100% and 96.3%, respectively). Cephalosporins, ceftazidime and cefuroxime were 100% resistant, while the fluoroquinolones Ciprofloxacin and Ofloxacin had a mean resistance of 40.7%. The moderate active antibiotic was streptomycin (44.4% susceptible). The poor monitoring of antibiotic usage, the abuse of their availability and the acquisition of resistance elements by organisms in hospitals and the community may be the causes of high antibiotic resistance

Item Type: Book Section
Uncontrolled Keywords: Antibiotic resistance  Hospitals  Pseudomonas aeruginosa
Subjects: Q Science > QH Natural history
Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Medicine, Health and Life Sciences > School of Biological Sciences
Depositing User: nwokealisi
Date Deposited: 17 May 2023 12:35
Last Modified: 17 May 2023 12:35

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