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Antibacterial kinetics and phylogenetic analysis of Aloe vera plants

Akinduti, P. A. and Obafemi, Yemisi Dorcas and Isibor, Patrick Omoregie and Ahuekwe, Eze Frank and Oduleye, O. S. and Oziegbe, Olubukola and Onagbesan, O. M. (2021) Antibacterial kinetics and phylogenetic analysis of Aloe vera plants. Macedonian Journal of Medical Sciences, 9. ISSN eISSN: 1857-9655

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BACKGROUND: Uncontrolled use of antibiotics has resulted in the emergence of resistant bacteria. It has necessitated the evaluation of antibacterial activities and phylo-diversity of Aloe vera (also called Aloe barbadensis) plants as antimicrobial agent in Nigeria. METHODS: Biotyped enteric bacilli of 251 strains obtained from fecal samples of patients with various gastro-intestinal complications are profiled for antibiogram. Resistant biotypes were assayed for susceptibility to A. vera latex and further evaluated for time-kill kinetics and phylo-diversity. RESULTS: More than 30% of enteric bacilli, including Citrobacter freundii, Escherichia coli, and Proteus mirabilis, were resistant to cotrimoxazole, ciprofloxacin, and tetracycline, respectively, at minimum inhibitory concentration (MIC) >16 μg/ml (p = 0.004). A. vera latex significantly inhibited 39.5% resistant enteric biotypes with a significant average reduction of the viable count at 1 × MIC and 2 × MIC to <3.0 Log10CFU/mL after 24 h. Flavonoids, alkaloids, terpenoids, and anthraquinine in anti-enteric sap significantly correlated and regressed with antibacterial activity (p < 0.05), while two of the antimicrobial A. vera plants showed phylogenetic relatedness with other homologous. CONCLUSION: Antibacteria efficacy of some Nigerian A. vera latex could provide alternative therapy, while its phylo-diversity and genomic profiling would offer a promising avenue for identification and development of antimicrobial agents as drug candidates for natural antibiotics.

Item Type: Article
Uncontrolled Keywords: Aloe vera; Sap; Resistant; Diversity, antibacterial
Subjects: Q Science > QH Natural history
Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Medicine, Health and Life Sciences > School of Biological Sciences
Depositing User: nwokealisi
Date Deposited: 26 May 2023 10:44
Last Modified: 26 May 2023 10:44

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