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Cytotoxic Assessment of Xylopia aethiopica [Dun.] A. on Human Prostate and Breast Cancer Cell Lines

Iweala, E. E. J. and Bankole, E.O. and Iheagwam, Franklyn N and Omoremime, E. Dania and Ntite, U.F. (2020) Cytotoxic Assessment of Xylopia aethiopica [Dun.] A. on Human Prostate and Breast Cancer Cell Lines. Tropical journal of natural product research, 4 (12). pp. 1143-1146. ISSN 2616-0692

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Cancer is associated with the unregulated multiplication of cells in specific parts of the body.Plant-derived products are employed in the treatment and management of such malignant tumours. Prostate and breast cancers are the most common forms affecting Nigerians. Our aim is to investigate the cytotoxic effect of Xylopia aethiopica, a commonly consumed spice in Nigeria, on selected cancer cell lines. The antiproliferative activity of X. aethiopica ethanol extract of varying concentrations was assessed on MDA-MB-231, MCF-7, and LNCaP using MTT assay. A dose-dependent antiproliferative activity was observed. The IC50 for X. aethiopica on the cell lines were ≤ 4.506 ± 0.07 µg/mL except for MCF-7 at 72 hours, where 18.86 ± 0.20 µg/mL was recorded. The findings from this study indicate the potential antiproliferative and cytotoxic property of X. aethiopica on human prostate and breast cancer cell lines.

Item Type: Article
Uncontrolled Keywords: Xylopia aethiopica, Cell viability, MDA-MB-231, LNCaP, Medicinal plants, Cancer.
Subjects: Q Science > QD Chemistry
Q Science > QH Natural history > QH301 Biology
R Medicine > R Medicine (General)
Divisions: Faculty of Medicine, Health and Life Sciences > School of Biological Sciences
Depositing User: AKINWUMI
Date Deposited: 07 Aug 2023 14:13
Last Modified: 07 Aug 2023 14:13

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