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Salami, Esther Abisola and Covenant University, Theses (2024) EFFECT OF BISPHENOL-A ON HORMONE AND LIPID LEVELS AMONG FIBROID PATIENTS IN LAGOS STATE, NIGERIA. Masters thesis, Covenant University.

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Leiomyomas are benign smooth muscle tumors that develop on the myometrium of the uterus. Research has shown that over 70% of women will have fibroids by the time they reach the age of 50. In recent times, there has been a growing concern regarding pollution of the environment, with reports indicating that synthetic chemicals possess the potential to disrupt the reproductive system by their endocrine-disrupting properties. Bisphenol-A (BPA) is one of the most produced endocrine disrupting chemicals in the world and this is as a result of industrialization and the increasing demand for plastics. The growth and development of uterine fibroids is regulated, in part, by hormone levels in the body. BPA has close structural similarity with estrogen; therefore it can act as both an estrogen mimic as well as an agonist of estrogen receptors. This study aimed to determine the levels of Bisphenol-A, hormones, and lipids and their relationship among fibroid patients in Lagos, Nigeria. The study was a cross-sectional study and involved 69 fibroid patients from the Gynaecology clinic at Lagos State University Teaching Hospital (LASUTH). Urinary BPA levels and plasma levels of vitamin D and estrogen in the patients were measured using an enzyme-linked immunosorbent assay (ELISA) technique. The plasma levels of high-density lipoprotein, triglycerides and cholesterol were measured spectrophotometrically. The mean concentration of BPA in the patients was 696.65 ng/ml and the median concentration was 39.67 ng/ml. The mean concentration of HDL-Triglycerides and HDL-Cholesterol were 14.35 mg/dl and 10.35 mg/dl respectively. The range of BPA concentrations (0.10 -15357.39 ng/ml) indicates that there is an exposure to BPA among Nigerian fibroid patients. Results of our study showed that patients in the high BPA group had a significantly higher level of HDL-Triglycerides (HDL-T) compared to those in the low BPA group (P<0.05). A statistically significant inverse relationship (β= -0.26; P<0.05) between Bisphenol-A and HDL-Cholesterol (HDL-C) was also detected. This study is the first to investigate the association between BPA, hormones, and lipids levels in Nigerian fibroid patients. Overall, this study provides suggestive evidence that exposure to BPA may alter the levels of plasma HDL-C and HDL-T in Nigerian fibroid patients.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Bisphenol-A, fibroids, lipids, estrogen, vitamin D
Subjects: Q Science > QH Natural history
Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Medicine, Health and Life Sciences > School of Biological Sciences
Depositing User: Patricia Nwokealisi
Date Deposited: 14 May 2024 12:15
Last Modified: 14 May 2024 12:17

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