NIR-II window absorbing graphene oxide-coated gold nanorods and graphene quantum dot-coupled gold nanorods for photothermal cancer therapy

Lebepe, Thabang C. and Parani, Sundararajan and Maluleke, Rodney and Ncapayi, Vuyelwa and Aladesuyi, O. and Komiya, Atsuki and Kodama, Tetsuya and Oluwafemi, Oluwatobi S. (2023) NIR-II window absorbing graphene oxide-coated gold nanorods and graphene quantum dot-coupled gold nanorods for photothermal cancer therapy. Nanotechnology Reviews.

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Abstract

Abstract: The graphene-based materials have been used as a potential coating material for nanoparticles due to their excellent passivation. Herein, we report for the first time the colloidal stability, photothermal profile, thermal stability, cytotoxicity, and photo-cytotoxicity of graphene quantum dots (GQDs) coupled with the second infrared window (NIR-II) absorbing gold nanorods (AuNRs/GQDs) and compare it to graphene oxide (GO)-coated NIR-II absorbing AuNRs (AuNRs/GO). The composites were achieved by electrostatic interaction of the GO or GQDs with AuNRs. The results revealed that (i) AuNRs/GQDs were more stable in the aqueous phosphate buffer and cell culture media than AuNRs/GO and AuNRs; (ii) GO enhanced the photothermal efficiency of the AuNRs, whereas GQDs reduced it; (iii) GQDs enhanced the photothermal stability of AuNRs than GO; (iv) both AuNRs/GO and AuNRs/GQDs were biocompatible with mouse colon carcinoma (C26) cell lines and malignant fibrous histiocytoma‐like, expressing a fusion of the luciferase and enhanced green fluorescent protein genes (KM-Luc/GFP) cell lines; and (v) photo-cytotoxicity of AuNRs/GO and AuNRs/GQDs conducted against C26 cell lines showed significantly improved cell death compared to laser irradiation alone; however, AuNRs/GO exhibited high photo-toxicity than AuNRs/GQDs. This study shows that AuNRs/GO and AuNRs/GQDs composites possess unique properties to improve AuNRs and be utilised in photothermal applications.

Item Type:	Article
Uncontrolled Keywords:	gold nanorods, graphene oxide, graphene quantum dots, stability, cytotoxicity, photothermal therapy
Subjects:	Q Science > QD Chemistry
Divisions:	Faculty of Engineering, Science and Mathematics > School of Chemistry
Depositing User:	ORIGBOEYEGHA
Date Deposited:	31 Jul 2024 12:35
Last Modified:	31 Jul 2024 12:35
URI:	http://eprints.covenantuniversity.edu.ng/id/eprint/18331

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