Rajendran, Jose Varghese and Parani, Sundararajan and Remya, Vasudevan Pillay R. and Lebepe, Thabang C. and Maluleke, Rodney and Aladesuyi, O. and Thomas, Sabu and Oluwafemi, Oluwatobi S. (2024) Preparation of β-Cyclodextrin Conjugated, Gelatin Stabilized SBA 15-CuInS2/ZnS Quantum Dot Nanocomposites for Camptothecin Release. Journal of Inorganic and Organometallic Polymers and Materials, 34. pp. 93-99.
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Abstract
Camptothecin (CPT) is a potential anticancer drug. However, it faces challenges due to its poor water solubility and the need for an efficient drug release system. Herein, we developed a novel system composed of gelatin stabilized, mesoporous silica SBA15 encapsulated CuInS2/ ZnS (CIS/ZnS) quantum dots (QDs) conjugated with β-cyclodextrin (β-CDs) for its potential use in the release of CPT. In this multifunctional system, β-CDs served as the drug carrier, SBA15 encapsulated QDs is capable of imaging and the gelatin was used to enhance the carrier-drug interaction. Fourier transform infrared (FTIR) analysis confirmed the successful conjugation of β-CDs to the Gel-SBA15 CIS/ZnS QDs, while optical analyses revealed excellent emission properties and high photostability. The β-CD-conjugated Gel-SBA15-CIS/ZnS QD nanocomposite was used to obtain the soluble derivate of CPT which further demonstrated a drug release profile following the triphasic model. Overall, the improved photostability and acceptable drug release profile of the β-CD conjugated Gel-SBA15-CIS/ZnS QD nanocomposite hold great promise for both imaging and therapeutic applications.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Quantum dots · Mesoporous silica · Photostability · Drug delivery |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Faculty of Engineering, Science and Mathematics > School of Chemistry |
| Depositing User: | ORIGBOEYEGHA |
| Date Deposited: | 01 Aug 2024 09:16 |
| Last Modified: | 01 Aug 2024 09:16 |
| URI: | http://eprints.covenantuniversity.edu.ng/id/eprint/18343 |
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