Kupolati, W.K. and Sadiku, Rotimi Emmanuel and Eze, A. A. and Ibrahim, Idowu David and Agboola, Oluranti (2022) Controlling the toxicity of antibiotics and metal nanoparticles by using polymers for the treatment of bacterial infection for medical applications. In: Polymeric Biomaterials for Healthcare Applications. Woodhead Publishing Series in Biomaterials, pp. 271-283.
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Abstract
The excessive intake of antibiotics in a quest to kill bacterial growth in the body results in antibiotic toxicity. This study investigated how to control the toxicity of antibiotics and metal nanoparticles by using polymers to treat bacterial infections for medical applications. The literature study determined that the control of toxicity of antibiotics and metallic nanoparticles could be achieved through encapsulation of antibiotics or metallic nanocomposites in biodegradable polymer-based therapy or by using biodegradable polymeric nanoparticles in delivering antimicrobial drugs. These can be obtained through the chemical conjugation of an antibiotic to a premade polymer through pendant group attachment or by polymerizing antibiotic-containing monomers. The physicochemical properties of polymers play a vital role, and the targeted polymerantibiotic conjugates are polymeric materials with good-quality antibacterial properties. Drug-resistant bacteria can be treated through the development of synergistic antibacterial therapy. In addition, a good sterilization process needs to be done on medical instruments and devices after they are used on a patient. The future use of polymer-based antibiotics could be as implants and as active and passive medical devices that can be applied during surgery.
| Item Type: | Book Section |
|---|---|
| Subjects: | R Medicine > RA Public aspects of medicine T Technology > TD Environmental technology. Sanitary engineering T Technology > TP Chemical technology |
| Divisions: | Faculty of Engineering, Science and Mathematics > School of Engineering Sciences |
| Depositing User: | Patricia Nwokealisi |
| Date Deposited: | 12 Mar 2025 13:12 |
| Last Modified: | 12 Mar 2025 13:12 |
| URI: | http://eprints.covenantuniversity.edu.ng/id/eprint/18867 |
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