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Facile Synthesis and Characterization of Substituted Pyrimidin-2(1H)-ones and their Chalcone Precursors

Ajani, O. O. and Ituen, R. I. and Falomo, A. (2011) Facile Synthesis and Characterization of Substituted Pyrimidin-2(1H)-ones and their Chalcone Precursors. Pakistan Journal of Scientific and Industrial Research, Series A: Physical Sciences, 54 (2). pp. 59-67. ISSN 2221-6413

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Abstract

A new and efficient method has been developed for the quantitative transformation of chalcones to pyrimidine frame work via solid support catalysis. Silica supported sulfuric acid (SSA) efficiently catalyzes the reaction of α,β-unsaturated carbonyl, chalcones (1-10) with urea to afford substituted pyrimidin-2(1H)-ones (11-20) in good to excellent yield. The interesting behaviour of SSA lies in the fact that it can be re-used after simple washing with chloroform thereby rendering this procedure more economical. The chemical structures were confirmed by analytical data as well as spectroscopic means.

Item Type: Article
Uncontrolled Keywords: catalyst; spectroscopic means; chalcones; 4-phenylbut-3-en-2-one
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Engineering, Science and Mathematics > School of Chemistry
Depositing User: Mr Olayinka O. AJANI
Date Deposited: 05 Dec 2013 09:54
Last Modified: 05 Dec 2013 09:54
URI: http://eprints.covenantuniversity.edu.ng/id/eprint/1933

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