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Synthesis and Antibacterial Activity of N,N-Diethyl-3-substituted-2-(4-methyl-phenylsulfonamido)alkanamides and their Arylsulfonamide Precursors

Ajani, O. O. and Familoni, O. B. and Wu, F. and Echeme, J. O. and Sujiang, Z. (2013) Synthesis and Antibacterial Activity of N,N-Diethyl-3-substituted-2-(4-methyl-phenylsulfonamido)alkanamides and their Arylsulfonamide Precursors. International Journal of Drug Design and Discovery, 4 (1). pp. 983-993. ISSN 0975-8275

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Abstract

A series of N,N-diethyl-3-substituted-2-(4-methylphenylsulfon amido)alkanamides (8a-k) and their arylsulfonamide precursors (7a-k) have been synthesized via facile approach. The chemical structures of the synthesized compounds were confirmed by analytical data and spectroscopic means. The in vitro antibacterial screening of these compounds along with streptomycin, showed N,N-diethyl-2-(4-methylphenylsulfonamido) -3-phenylpropanamide (8j) to be the most active agent on Escherichia coli at MIC of 12.5 μg/mL and on Staphylococcus aureus at MIC of 25 μg/mL.

Item Type: Article
Uncontrolled Keywords: in vitro stability; antibacterial activity; sulphonylation; substituted amide
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Engineering, Science and Mathematics > School of Chemistry
Depositing User: Mr Olayinka O. AJANI
Date Deposited: 05 Dec 2013 09:54
Last Modified: 05 Dec 2013 09:54
URI: http://eprints.covenantuniversity.edu.ng/id/eprint/1934

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