Cu(II) and Fe(III) complexes of sulphadoxine mixed with pyramethamine: Synthesis, characterization, antimicrobial and toxicology study

Ogunniran, K. O. and Ajani, O. O. and Ehi-Eromosele, C. O. and Obaleye, J. A. and Adekoya, J. A. and Ajanaku, K. O. (2012) Cu(II) and Fe(III) complexes of sulphadoxine mixed with pyramethamine: Synthesis, characterization, antimicrobial and toxicology study. International Journal of Physical Sciences, 7 (13). pp. 1998-2005. ISSN 1992 - 1950

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Abstract

Two new mixed ligands metal complexes of sulphadoxine and pyramethamine were prepared by using CuCl2.6H2O and FeCl3.6H2O. The complexes were characterized by elemental analysis, melting point determination, molar conductivity, metal content analysis (AAS), IR, magnetic susceptibility measurements and UV-Visible spectroscopy. Based on the analytical and spectroscopic data, the complexes were proposed to have the formulae [M1L1L2(Cl)2] and [M2L1L2(Cl)3] (where M1 = Cu(II), M2 = Fe(III)), L1 = sulphadoxine, L2 = pyramethamine). The spectroscopic data proposed L1 to be a monodentate ligand and coordinated through N atom of the NH2 group in both complexes. Also, L2 was proposed to be tridentate ligand and coordinated through N atom of the NH2 groups and through N atom of imine group. However, [M1L1L2(Cl)2] and [M2L1L2(Cl)3] were proposed to possess distorted octahedral geometry. Conductivity measurement values supported the non-electrolytic nature of the complexes. The complexes have been tested in vitro against a number of pathogenic bacteria [g(+) Escherichia coli, g(+) Proteus species, g(+) Pseudomonas aeruginosa and g(+) Salmonella typhi] by using disc diffusion method. Obtained results indicated that the metal complexes exhibited better antibacterial activities as compared to the ligands. Toxicology tests against some tissues of albino rat (Rattus novergicuss) revealed toxicity of the complexes in the kidney as compared to the parent drugs. [M1L1L2(Cl)2] was found to be toxic to the sera, livers and kidneys of the rats used, while [M2L1L2(Cl)3] was found to be non-toxic to the sera, livers and kidneys of the rats as their alkaline phosphatase (ALP) values showed non-significant difference to the control values

Item Type:	Article
Uncontrolled Keywords:	Metal complexes, complexation, antibiotics, antimicrobial properties, alkaline phosphatase
Subjects:	Q Science > QD Chemistry
Divisions:	Faculty of Engineering, Science and Mathematics > School of Chemistry
Depositing User:	Mr Olayinka O. AJANI
Date Deposited:	05 Dec 2013 09:54
Last Modified:	29 Oct 2014 10:24
URI:	http://eprints.covenantuniversity.edu.ng/id/eprint/1937

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