Phytochemical Screening and in vivo antioxidant activity of Ethanolic extract of caesalpinia bondus (L.) Roxb

Ogunlana , O. O and Ogunlana , O. E and Ntube , C. A and Olagunju , J. A and Akindahunsi , A. A (2012) Phytochemical Screening and in vivo antioxidant activity of Ethanolic extract of caesalpinia bondus (L.) Roxb. Global research journal of PHARMACEUTICAL SCIENCES.

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Abstract

Phytochemical screening, antioxidant activity in vivo and lipid peroxidation of 75 % ethanolic extract of young twigs and leaves of Caesalpinia bonduc were carried out by chemical test, and assessment of catalase and peroxidase activities and lipid peroxidation in Wistar rats after oral administration of different concentrations of the plant extract for ten days. Phytochemical screening of the extract revealed the presence of all major classes of phytochemicals: tannins, flavonoids, saponin, steroids, terpenoids, cardiac glycosides, glycosides, except phlobatannins. There were significant (p<0.05) graded increase in catalase and peroxidase activities and decrease in TBARS concentrations in the extract tested rats in comparison with normal control, Vitamin C and amodiaquine tested rats. The various pharmacological activities of C. bonduc may be due to its antioxidant activity.

Item Type:	Article
Subjects:	Q Science > QD Chemistry
Divisions:	Faculty of Engineering, Science and Mathematics > School of Chemistry
Depositing User:	Mrs Patricia Nwokealisi
Date Deposited:	15 Jan 2014 06:27
Last Modified:	15 Jan 2014 06:27
URI:	http://eprints.covenantuniversity.edu.ng/id/eprint/2017

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