Effects of combinations of ethanolic extracts of Blighia sapida and Xylopia aethiopica on progesterone, estradiol and lipid profile levels in pregnant rabbits

Odesanmi, O. S. and Ayepola, O.O and Omotosho, O. E. and Ogunlana, Olubanke Olujoke and Onwuka, Frank and Nwankpa, Promise (2013) Effects of combinations of ethanolic extracts of Blighia sapida and Xylopia aethiopica on progesterone, estradiol and lipid profile levels in pregnant rabbits. Scientific Research and Essay, 8 (22). pp. 969-972. ISSN ISSN 1992-2248

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Abstract

The effects of ethanolic extracts of Xylopia aethiopica fruits and Blighia sapida roots, used by some rural dwellers in western part of Nigeria for arbortifacient purposes, were investigated using pregnant rabbits. A combination of X. aethiopica and B. sapida in a ratio 1:1 at concentrations of 10.0 mg/ kg body weight (group B) and 50.0 mg/ kg body weight (group C), and X. aethiopica alone at 50.0 mg/kg of body weight (group D) were administered by gastric intubations for a period of 14 days from the 12th to 25th day of gestation after which they were fasted for 18 h. Serum levels of reproductive hormones (progesterone and estradiol) and lipids (triglycerides, total cholesterol, LDL-cholesterol and HDLcholesterol) were determined at the end of the treatment. Results showed significant reductions (p < 0.05) in progesterone and estradiol levels, significant elevations of triglycerides (p < 0.05) and no statistically significant differences (p < 0.05) in the levels of total cholesterol in all the treated groups compared with the control (group A). There was a statistically significant reduction (p < 0.05) in the levels of HDL-cholesterol in Group B, a significant increase in group C and no significant reduction in group D compared with the control (group A). The levels of LDL-cholesterol in all the treated groups did not differ significantly (p < 0.05) from the control (group A). The results suggest that ethanolic extracts of X. aethiopica alone or in combination with B. sapida may actually lead to termination of pregnancy due to reduction of progesterone and estradiol. The results also suggest that there is increased risk of hypertriglyceridemia in the users of these plants but this may not predispose them to arteriosclerosis because of the insignificant differences in the levels of LDL-cholesterol in all the treated groups compared with the control.

Item Type:	Article
Subjects:	Q Science > Q Science (General)
Divisions:	Faculty of Medicine, Health and Life Sciences > School of Biological Sciences
Depositing User:	Mrs Patricia Nwokealisi
Date Deposited:	24 Jan 2014 10:58
Last Modified:	24 Jan 2014 10:58
URI:	http://eprints.covenantuniversity.edu.ng/id/eprint/2067

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