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Synthesis, physical properties, antimicrobial potentials of some mixed antibiotics complexed with transition metals and their effects on alkaline phosphatase activities of selected rat tissues

Ogunniran, K. O. and Ajanaku, K. O. and James, O. O. and Ajani, Olayinka O. and Nwinyi, Obinna and Omonhinmin, A. C. and Allensela, M. A. (2008) Synthesis, physical properties, antimicrobial potentials of some mixed antibiotics complexed with transition metals and their effects on alkaline phosphatase activities of selected rat tissues. Scientific Research and Essay, 3 (8). pp. 348-354. ISSN 1992-2248

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Abstract

Mixed ligand metal complexes of chloramphenicol and oxytetracycline were prepared by using Ni(II), Co(II) and Fe(III) metal chloride hexahydrate. They were characterized based on some physical technique and spectroscopic analysis such as AAS, UV, and IR spectroscopy. Based on the analytical and spectroscopic data, the complexes were proposed to have the formulae [ML1L2](Cl)n (where M = Ni(II), Co(II), Fe(III); L1 = chloramphenicol, L2 = oxytetracycline and n = 2 - 3). IR spectra suggested that both L1 and L2 coordinated to the metal ions in a terdentate manner with �(O-H), �(C=O) and �(N-H) as donor sites in each of the ligands. The complexes were proposed to be of octahedral. The synthesized complexes, in compares to their ligands, were screened for their antibacterial activity against isolated strains of Escherichia coli, Staphylococcus aureus and Klebsiella pneumonia by using diffusion method. The activity data showed the metal complexes to be more potent antibacterial than the parent drugs against the three species. Toxicology tests against some tissues of albino rat (Rattus novergicuss) revealed toxicity of the complexes as compared to the parent drugs. Ni(II) complex was found to possess no significant difference (P > 0.05) in alkaline phosphatase from both homogenates of liver and kidney and rat serum. However, Co(II) and Fe(III) complexes were found to significantly increase (P < 0.05) alkaline phosphatase from homogenates of liver and kidney tissues of the tested doses but there was no significant difference (P > 0.05) in alkaline phosphatase from rat serum.

Item Type: Article
Subjects: Q Science > QD Chemistry
Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Medicine, Health and Life Sciences > School of Biological Sciences
Depositing User: Mr Adewole Adewumi
Date Deposited: 22 Jun 2011 22:57
Last Modified: 13 Dec 2011 21:13
URI: http://eprints.covenantuniversity.edu.ng/id/eprint/220

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