Rosen, Barry P. and Hsu, Ching-Mei and Karkaria, Cyrus E. and Kaur, Parjit and Owolabi, Joshua B. and Tisa, Louis S. (1990) A plasmid-encoded anion-translocating ATPase. Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1018 (2-3). pp. 203-205.
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Abstract
An anion-translocating ATPase has been identified as the product of the arsenical resistance operon of resistance plasmid R773. When expressed in Escherichia coli this ATP-driven oxyanion pump catalyzes extrusion of the oxyanions arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces resistance to the toxic agents. The pump is composed of two polypeptides, the products of the arsA and arsB genes. This two-subunit enzyme produces resistance to arsenite and antimonite. A third gene, arsC, expands the substrate specificity to allow for arsenate pumping and resistance.
Item Type: | Article |
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Uncontrolled Keywords: | • ATPase; • Ion transport; • Anion pump; • Arsenic; • Antimony; • Plasmid resistance |
Subjects: | Q Science > QH Natural history > QH301 Biology R Medicine > R Medicine (General) |
Divisions: | Faculty of Medicine, Health and Life Sciences > School of Biological Sciences |
Depositing User: | Mrs Patricia Nwokealisi |
Date Deposited: | 20 Oct 2014 12:18 |
Last Modified: | 20 Oct 2014 12:18 |
URI: | http://eprints.covenantuniversity.edu.ng/id/eprint/2846 |
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