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A plasmid-encoded anion-translocating ATPase

Rosen, Barry P. and Hsu, Ching-Mei and Karkaria, Cyrus E. and Kaur, Parjit and Owolabi, Joshua B. and Tisa, Louis S. (1990) A plasmid-encoded anion-translocating ATPase. Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1018 (2-3). pp. 203-205.

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An anion-translocating ATPase has been identified as the product of the arsenical resistance operon of resistance plasmid R773. When expressed in Escherichia coli this ATP-driven oxyanion pump catalyzes extrusion of the oxyanions arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces resistance to the toxic agents. The pump is composed of two polypeptides, the products of the arsA and arsB genes. This two-subunit enzyme produces resistance to arsenite and antimonite. A third gene, arsC, expands the substrate specificity to allow for arsenate pumping and resistance.

Item Type: Article
Uncontrolled Keywords: • ATPase; • Ion transport; • Anion pump; • Arsenic; • Antimony; • Plasmid resistance
Subjects: Q Science > QH Natural history > QH301 Biology
R Medicine > R Medicine (General)
Divisions: Faculty of Medicine, Health and Life Sciences > School of Biological Sciences
Depositing User: Mrs Patricia Nwokealisi
Date Deposited: 20 Oct 2014 12:18
Last Modified: 20 Oct 2014 12:18

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