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In-vivo Antiplasmodial Activity of Crude n-hexane and Ethanolic Extracts of Moringa oleifera (LAM.) Seeds on Plasmodium berghei

Olasehinde, G. I and Ayanda, Opeyemi Isaac and Ajayi, A. A. and Nwabueze, A. P. (2012) In-vivo Antiplasmodial Activity of Crude n-hexane and Ethanolic Extracts of Moringa oleifera (LAM.) Seeds on Plasmodium berghei. International Journal of Medicinal Plant Research, 1 (5). pp. 50-54. ISSN 2169-303X

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Abstract

Studies were carried out to determine the antiplasmodial activity of crude n-hexane and ethanolic seed extracts of Moringa oleifera using cold extraction method. Twenty-four albino mice (Mus musculus) induced intraperitoneally with chloroquine sensitive Plasmodium berghei strain were divided into 4 groups and treated at three concentrations viz: 50, 100 and 200 ml/kg. Positive control was set up with chloroquine diphosphate while negative control was set up with olive oil. The mice models were treated for 72 h. For the ethanolic extract, a parasite inhibition rate of 61% was observed at concentration 50 ml/kg, 65% at concentration 100 ml/kg and 100% at concentration 200 ml/kg in day 3 after treatment. In n-hexane extract of the seeds of M. oleifera, plasmodial inhibition rate of 61% was observed at concentration 50 ml/kg, 70% at concentration 100 ml/kg and 97% at concentration 200 ml/kg after treatment for 72 h. A 100% inhibition rate was observed for mice treated with 25 mg/kg of standard chloroquine diphosphate after day 3 of treatment while parasitaemia increased from 48 on day 0 to 86 after day 3 for mice treated with olive oil. Overall, crude ethanolic extract of M. oleifera seed showed higher parasite inhibition activity than the crude n-hexane extract

Item Type: Article
Uncontrolled Keywords: Antiplasmodial, parasitaemia, Moringa oleifera, n-hexane, ethanolic
Subjects: Q Science > QH Natural history > QH301 Biology
Q Science > QR Microbiology
Divisions: Faculty of Medicine, Health and Life Sciences > School of Biological Sciences
Depositing User: Mr Solomon Bayoko
Date Deposited: 17 Jan 2015 19:30
Last Modified: 17 Jan 2015 19:30
URI: http://eprints.covenantuniversity.edu.ng/id/eprint/3340

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