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Microwave-Assisted Synthesis and Antibacterial Activity of some Pyrazol-I-Ylquinoxalin-2(IH)-One Derivatives

Ajani, Olayinka O. and Obafemi, C. A. and Ikpo, C. O. and Ogunniran, K. O. and Nwinyi, Obinna (2009) Microwave-Assisted Synthesis and Antibacterial Activity of some Pyrazol-I-Ylquinoxalin-2(IH)-One Derivatives. ХИМИЯ ГЕТЕРОЦИКЛИЧЕСКИХ СОЕДИНЕНИЙ (11). pp. 1703-1713.

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Abstract

3-Hydrazinoquinoxalin-2(1H)-one was prepared from quinoxaline-2,3-dione and subsequently used for the synthesis of some potentially biologically active 3-(pyrazol-1-ylquinoxalin-2(1H)-one derivatives. While 3-(3,5-dimethylpyrazol-1-yl)quinoxalin-2(1H)-one showed a comparative effect with streptomycin, 3-(5-oxo-3-phenyl-4,5-di- hydropyrazol-1-yl)quinoxalin-2(1H)-one was found to be the most active at MIC value of 7.8 μg/ml

Item Type: Article
Uncontrolled Keywords: 3-hydrazinoquinoxalin-2(1H)-one, imines, gram-positive bacteria
Subjects: Q Science > QD Chemistry
Q Science > QH Natural history > QH301 Biology
Q Science > QR Microbiology
Divisions: Faculty of Medicine, Health and Life Sciences > School of Biological Sciences
Depositing User: Mr Solomon Bayoko
Date Deposited: 19 Jan 2015 10:27
Last Modified: 19 Jan 2015 10:38
URI: http://eprints.covenantuniversity.edu.ng/id/eprint/3356

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