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Microwave assisted synthesis and antimicrobial activity of 2-quinoxalinone-3-hydrazone derivatives

Ajani, Olayinka O. (2010) Microwave assisted synthesis and antimicrobial activity of 2-quinoxalinone-3-hydrazone derivatives. Bioorganic and Medicinal Chemistry, 18 (1). pp. 214-221. ISSN 0968 - 0896

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A simple and efficient method has been developed for the synthesis of various 2-quinoxalinone-3-hydrazone derivatives using microwave irradiation technique. The series of 2-quinoxalinone-3-hydrazone derivatives synthesized, were structurally confirmed by analytical and spectral data and evaluated for their antimicrobial activities. The results showed that this skeletal framework exhibited marked potency as antimicrobial agents. The most active antibacterial agent was 3-{2-[1-(6-chloro-2-oxo-2H-chromen-3-yl)ethylidene]hydrazinyl}quinoxalin-2(1H)-one, 7 while 3-[2-(propan-2-ylidene)hydrazinyl]quinoxalin-2(1H)-one, 2 appeared to be the most active antifungal agent.

Item Type: Article
Uncontrolled Keywords: 3-Hydrazinoquinoxalin-2(1H)-one; Antibacterial activity; Gram positive bacteria; Microwave irradiation
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Engineering, Science and Mathematics > School of Chemistry
Depositing User: Mr Olayinka O. AJANI
Date Deposited: 29 Jun 2011 20:59
Last Modified: 13 Dec 2011 21:13

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