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Effects of Fibre-Enriched Diets on Tissue Lipid Profiles of MSG Obese Rats

Rotimi, Oluwakemi A and Olayiwola, I.O. and Ademuyiwa, Oladipo and Balogun, Elizabeth A. (2012) Effects of Fibre-Enriched Diets on Tissue Lipid Profiles of MSG Obese Rats. Food and Chemical Toxicology, 50. pp. 4062-4067.

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In order to investigate the influence of some fibre-enriched diets on tissue lipids in an animal model of obesity induced by the administration of monosodium glutamate (MSG), obese rats were fed diets containing 30% of Acha, Cassava, Maize and Plantain for five weeks and weight gain, feed intake and lee index were recorded. The lipid profiles of plasma, erythrocytes, kidney, heart and liver as well as hepatic 3- hydroxyl-3-methylglutaryl-CoA (HMG-CoA) reductase activity were measured. The diets significantly (p < 0.05) reduced weight gain and lee index in the obese rats. Obesity-induced increase in plasma and erythrocytes lipid levels was significantly (p < 0.05) reduced by these diets. MSG-induced obesity also resulted in a significant increase (p < 0.05) in hepatic cholesterol level which was reduced by the diets. MSG-obesity was characterised by a significant (p < 0.05) increase in cholesterol, triacylglycerol and phospholipids in kidney and this was reversed by the diets except Maize which did not reverse the increased cholesterol level. Only Acha reversed the obesity-induced increase in heart cholesterol and phospholipids. The increased activity of hepatic HMG-CoA reductase associated with obesity was also significantly (p < 0.05) reduced by the diets. In conclusion, dyslipidemia associated with MSG-induced obesity could be attenuated by consumption of fibre-enriched diets

Item Type: Article
Uncontrolled Keywords: MSG, Fibre, Obesity, Dyslipidemia, HMG-CoA reductase,
Subjects: Q Science > QD Chemistry
Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Medicine, Health and Life Sciences > School of Biological Sciences
Depositing User: Mr Solomon Bayoko
Date Deposited: 06 Feb 2015 12:22
Last Modified: 22 Mar 2018 09:48

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