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Bacteriological And Clinical Evaluation Of Twelve Cases Of Post-Surgical Sepsis Of Odontogenic Tumors At A Referral Centre

Egwari, L. O. and Nwokoye, N. N. and OBISESAN, B and COKER, A.O and NWAOKORIE, F.A and SAVAGE, K.O (2008) Bacteriological And Clinical Evaluation Of Twelve Cases Of Post-Surgical Sepsis Of Odontogenic Tumors At A Referral Centre. EAST Af-RICAN MEDICAL JOURNAL. pp. 269-274.

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Objective: To detennine the bacterial aetiology of sepsis occurring following surgery of odontogenic tumours and assess the effect of prompt and proper antibiotic usage. Desigu: A prospective study. Settiug: A tertiary referral centre in Lagos, Nigeria. . . Subjects: Twelve patients with odontogenic tumours that developed sepsis postoperatively. Eight of the patients were referred from private hospitals, the remaining were in-patients who sought for alternative medical attention following interruption of health care services at the referral cenlre. TutenJmtiou: Adequate review of patient's medical history, bacteriological investigations and antibiotic therapy. Mniu outcome measures: Bacteriological and clinic~! cure following antibiotic therapy based on susceptibility test results. Results: Two categories of patients were identified; those who completed the course of antibiotics prescribed post-surgery and patients who failed to conform to antibiotic prescription. Sepsis developed in the non-compliance group much earlier than in the group that complied (p<0.001). Infections were polybacterial with aerobes accounting for 77.4% (a-haemolytic streptococci 29.0%, Streptococcus pyogenes 16.1%, ~tapllylococcus aureus 16.1%, diphtheroids 9.7%, Klebsiella puemnouiae 6.5%) and anaerobes 22.6% (Porpltyromonas gingiva lis 9.7%, Peptostreptococcus spp. 6.5%, Prevotella melnninogenica 3.2%, Clostridium perfringeus 3.2%). Mixed aerobic and anaerobic aetiology occurred more in osteosarcoma and fibrosarcoma. Clostridium perfriugens was isolated from a case of osteosarcoma with necrotic tissues. The anaerobic bacteria were 100% sensitive to metronidazole, ciprolloxacin and augmentin, 65-85% sensitivity to ampicloxacillin, amoxicillin and erythromycin. Over 92% of the streptococci were sensitive to the P-Lactams contrast low susceptibility with S. aureus and K. pnemnoniae. Couclusion: Interruption of healthcare service was the sole factor identified in the development of sepsis as the patients could not be monitored to ensure compliance to prescription

Item Type: Article
Subjects: Q Science > QH Natural history > QH301 Biology
Q Science > QR Microbiology
Divisions: Faculty of Medicine, Health and Life Sciences > School of Biological Sciences
Depositing User: Mrs Hannah Akinwumi
Date Deposited: 31 Mar 2015 15:18
Last Modified: 31 Mar 2015 15:18

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