Rotimi, Solomon and Ugwu, Emmanuel and Essien, Imaobong and Adelani, Isaacson and Rotimi, Oluwakemi A (2015) Effects of Quercetin and α-Lipoic Acid on α-Cypermethrin-Induced Oxidative Stress in Rats. The FASEB Journal, 29 (1 Supp). pp. 612-2.
Full text not available from this repository.Abstract
This study evaluated the effects of quercetin and α-lipoic acid on the antioxidant status of α-Cypermethrin (α-CYP) treated rats. 30 rats were randomly divided five experimental groups thus: (i) control group, (ii) α-CYP alone (14.5 mg kg-1 body weight/day, p.o.), (iii) α-CYP (14.5 mg kg-1body weight/day, p.o.) and α-lipoic acid (20 mg kg-1body weight/day, p.o.) 1h later, (iv) α-CYP (14.5 mg kg-1body weight/day, p.o.) and quercetin (20 mg kg-1body weight/day, p.o.) 1h later (v) α-lipoic acid alone (vi) quercetin alone. After two weeks of treatment, the rats were sacrificed and blood collected by cardiac puncture and organs were excised for the assay of the activities of antioxidant enzymes and levels reduced glutathione (GSH) and lipid peroxidation. α-CYP induced a significant (p<0.05) decrease in the activity of superoxide dismutase (SOD) in liver and kidney; and that of glutathione-S-tranferase (GST) in liver and erythrocytes. There was also a significant (p<0.05) decrease in the level of GSH in liver, brain and kidney. α-lipoic acid administration with α-CYP induced a significant (p<0.05) increase in activity of SOD in liver and levels of GSH in liver, kidney and brain. α-lipoic acid also induced a significant (p<0.05) decrease in GST activity and lipid peroxidation level in liver and RBC. Quercetin administration had similar effect as alpha-lipoic acid, only that there was no significant (p>0.05) difference in SOD activity in liver. The results demonstrated that administration of α-lipoic acid or quercetin to α-CYP treated rats exerted protective role against oxidative stress and lipid peroxidation.
| Item Type: | Article |
|---|---|
| Subjects: | Q Science > Q Science (General) |
| Divisions: | UNSPECIFIED |
| Depositing User: | Solomon Rotimi |
| Date Deposited: | 20 Apr 2015 13:48 |
| Last Modified: | 22 Mar 2018 09:52 |
| URI: | http://eprints.covenantuniversity.edu.ng/id/eprint/4823 |
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