Inhibitory activity of Detarium microcarpum extract against hepatitis C virus

OLUGBUYIRO, J.A.O (2009) Inhibitory activity of Detarium microcarpum extract against hepatitis C virus. African Journal of Biomedical Research, 12 (2). pp. 149-151. ISSN 1119-5096

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Abstract

Bioassay guided fractionation of the methanolic extract of Detarium microcarpum Guill using VLC and activity against hepatitis C virus in the Huh-7 Replicon assay was done. The active fraction MTH-1700 which demonstrated good inhibitory and selective potency (83.87%) against Hepatitis C Virus and comparable with 86.76% of the control; RS-446(2-Me-C) at a concentration of 10 µM was further fractionated by HPLC. Keywords: Detarium microcarpium; Anti-viral activity; Hepatitis; Cytotoxicity.

Item Type:	Article
Subjects:	Q Science > QD Chemistry Q Science > QK Botany R Medicine > RM Therapeutics. Pharmacology
Divisions:	Faculty of Engineering, Science and Mathematics > School of Chemistry
Depositing User:	MR JOSEPH OLUGBUYIRO
Date Deposited:	31 Aug 2011 14:51
Last Modified:	13 Dec 2011 21:14
URI:	http://eprints.covenantuniversity.edu.ng/id/eprint/507

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