De, N and Gabriel, P (2004) Explorative study of anticoagulant activities of extracts of Swietenia mahogany, Cissampellos mucronatta and Heckeria insignis. Nigerian Journal of Basic and Applied Sciences, 13. pp. 67-75.
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Abstract
The bark of Swietenia mahogany, the roots of Cissampellos mucronatta and the seeds of Heckeria insignis were extracted with water, methanol and carbon tetrachloride respectively. Each extract was filtered and concentrated under vacuum at 4CfC and then were used as anticoagulant agents using whole blood clotting time method. All the control values obtained (5.4 minutes -5.9 minutes) lie within the reported normal range for blood coagulation time. The mean coagulation time obtained for all the extracts of roots of Cissampellos mucronatta were longer (6.0 minutes- 7.5 minutes) than their controls but the difference was not significant. The water and methanol extracts of the bark of Swietenia mahogany and seeds of Heckeria insignis possess anticoagulant activities (the mean coagulation time observed for each of these extracts was more than 24 hours). However, the carbon tetrachloride extract did not show any significant anticoagulant activities. Preliminary phytochemical analysis showed that bark of Swietenia mahogany possesses terpenes and steroids whereas roots of Cissampellos mucronatta and seeds of Heckeria insignis possess tannins and saponins. These results are of interest because Cissampellos mucronatta and Heckeria insignis are used locally for treating snake bites and small cuts in some parts of Adamawa State, Nigeria.
| Item Type: | Article |
|---|---|
| Subjects: | Q Science > Q Science (General) Q Science > QC Physics |
| Divisions: | Faculty of Engineering, Science and Mathematics > School of Physics |
| Depositing User: | Mrs Hannah Akinwumi |
| Date Deposited: | 21 Apr 2015 13:15 |
| Last Modified: | 21 Apr 2015 13:15 |
| URI: | http://eprints.covenantuniversity.edu.ng/id/eprint/5074 |
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