De, Nandita B. (1999) Strategies For Enhanced Production And Recovery Of Cyclosporine. Nig. J. Biotechn, 10 (1). pp. 47-54.
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Abstract
An investigation was made on the improved production and r~covery of the new and potent immunos..:opressiv~ i)eptide, cyclosporine (cyclo~porin A, Cy A) from a glucose-adapted isolate_ of the fungus i. ~ J/C,<...ladiurn inflaturn. Among the amino acid members in the Cy A molecule, L-leucine and especially L-valin~:t had a strong positive effect on production of Cyclosporine. ·When other conStituent amino acids were added with L-valine, negative effe.cts were obseiVed. Optimal time of L-valine was 48 . ' . tus. In the case of semisynthetic medium and its optimal amount-was 4·gramslliter (g/1). Considerable improvements in the recovery of this drug were, ~~ieved by modifying ul~ available extraction pro~edure with the addition of surfactant, or With alkali apqilion followed by moqerate heat treatmEmt
| Item Type: | Article |
|---|---|
| Subjects: | Q Science > Q Science (General) Q Science > QH Natural history > QH301 Biology |
| Divisions: | Faculty of Medicine, Health and Life Sciences > School of Biological Sciences |
| Depositing User: | Mrs Hannah Akinwumi |
| Date Deposited: | 21 Apr 2015 13:49 |
| Last Modified: | 21 Apr 2015 13:49 |
| URI: | http://eprints.covenantuniversity.edu.ng/id/eprint/5076 |
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