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Strategies For Enhanced Production And Recovery Of Cyclosporine

De, Nandita B. (1999) Strategies For Enhanced Production And Recovery Of Cyclosporine. Nig. J. Biotechn, 10 (1). pp. 47-54.

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An investigation was made on the improved production and r~covery of the new and potent immunos..:opressiv~ i)eptide, cyclosporine (cyclo~porin A, Cy A) from a glucose-adapted isolate_ of the fungus i. ~ J/C,<...ladiurn inflaturn. Among the amino acid members in the Cy A molecule, L-leucine and especially L-valin~:t had a strong positive effect on production of Cyclosporine. ·When other conStituent amino acids were added with L-valine, negative effe.cts were obseiVed. Optimal time of L-valine was 48 . ' . tus. In the case of semisynthetic medium and its optimal amount-was 4·gramslliter (g/1). Considerable improvements in the recovery of this drug were, ~~ieved by modifying ul~ available extraction pro~edure with the addition of surfactant, or With alkali apqilion followed by moqerate heat treatmEmt

Item Type: Article
Subjects: Q Science > Q Science (General)
Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Medicine, Health and Life Sciences > School of Biological Sciences
Depositing User: Mrs Hannah Akinwumi
Date Deposited: 21 Apr 2015 13:49
Last Modified: 21 Apr 2015 13:49

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