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Studies On Antibacterial Effect Of Newbouldia laevis And Aspilia a.fricana

De, Nandita B. and Nanja, N. A. (2001) Studies On Antibacterial Effect Of Newbouldia laevis And Aspilia a.fricana. Bagale Journal of Pure and Appljed Sciences,, 1 (1). pp. 24-29.

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Preliminary phytochemical analysis showed that the leaves and stem bark of Newbou/dia /aevis and the leaves and inflorescence of Aspilia africana possess phenolic compounds (including tannins) and saponins. Antimicrobial activity of aqueous, methanol and acetone extracts of the leaves and stem bark of N.laevis and the leaves and inflorescence of A.africana were studied by agar diffusion method. Our results confirm the basis of traditional use of these two plants in wound dressing. The methanol extracts ofthe stem bark of N. laevis and florescence of A. ajricana produced the strongest definite antimicrobial activities against Strepl,lCOccus faecaiis, Clostridium tetani, Clostridium perfringens, Nocardia asteriodes, Serratia marcescens anci Proteu~· mirabilis. The acetone extract of both plant parts produced less activity than the methanol extracts. !h~ aquenus extracts did not exhibit any significant antibacterial activity. Warming to 60"C significantly increased the sensitivity of the acetone extract of A. afi'icana to the test organisms. At pH 2 and pH 8 the sensitivity of the extracts to the test organisms was same to the non treated extracts. The MIC (0.60-0.85mg/ml) and MBC (0.70-1.02 mg/ml) of the methanol extracts of both plant parts were higher than those of tetracycline and gentamycin (M!C- 0.20-0.35 and MBC 0.30-0.50).

Item Type: Article
Subjects: Q Science > Q Science (General)
Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Medicine, Health and Life Sciences > School of Biological Sciences
Depositing User: Mrs Hannah Akinwumi
Date Deposited: 21 Apr 2015 14:21
Last Modified: 21 Apr 2015 14:21

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