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Transition Metal Complexes of (E)-N’- 4-cyanobenzylidene)nicotinohydrazide): Synthesis, Structural and Anti-Mycobacterial Activity Study

Ogunniran, K. O. and Adekoya, J. A. and Ehi-Eromosele, C. O. and Siyanbola, T. O. and Kayode, Akinlolu and Mesubi, M. A. and Narender, T. (2015) Transition Metal Complexes of (E)-N’- 4-cyanobenzylidene)nicotinohydrazide): Synthesis, Structural and Anti-Mycobacterial Activity Study. Journal of Applied Sciences, 15 (10). pp. 1210-1222. ISSN 1812-5654

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Abstract

One step condensation of nicotinic acid hydrazide and 4-cyanobenzaldehyde formed a bidentate acylhydrazone ligand (HL5). The acylhydrazone was characterized by ESI mass spectrometer, CHN analyzer, IR spectrometer, 1H-NMR, 13C-NMR and 2D NMR (COSY and HSQC). Thereafter, Mn(II), Mo(V), Fe(II),Cu(II) and Zn(II) complexes of the cylhydrazone ligand were synthesized and characterized based on conductivity measurements, melting point determination, CHN analysis, AAS, magnetic measurement, UV/Visible study, IR spectroscopy, ESR and TGA/DTA studies. The information obtained corroborated results from powder X-ray analysis to arrive at the model structures for the complexes. In vitro antimycobacterial properties of the compounds were evaluated against Mycobacterium tuberculosis H37Rv by using micro-diluted method. The result obtained revealed that HL5, Mn(II), Mo(V), Cu(II) and Zn(II) complexes exhibited promising antitubercular activity. Zn(II) complex had the highest MIC value of 0.62 μg MLG1, while Fe(II) complex exhibited the lowest MIC value of 1.15 μg MLG1. However, the result of cytotoxicity study indicated that acylhydrazone and Zn(II) complex with IC50 of 2.17 and 1.72 μM, respectively were not toxic compared to isoniazid. Mn(II) complex was however found to be the most toxic.

Item Type: Article
Uncontrolled Keywords: Corresponding Author: Kehinde O. Ogunniran Department of Chemistry, College of Science and Technology, Covenant University, Ota, Ogun State, Nigeria
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Engineering, Science and Mathematics > School of Chemistry
Depositing User: Dr Joseph Adeyemi Adekoya
Date Deposited: 26 Oct 2015 14:28
Last Modified: 16 Jan 2017 12:25
URI: http://eprints.covenantuniversity.edu.ng/id/eprint/5613

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